Moghissi KS

ObjectiveTo examine the relationship of ovulation-stimulating drugs to risk of cancers other than breast and gynecologic malignancies.DesignRetrospective cohort study, with additional follow-up since initial report.SettingReproductive endoc…

BackgroundAlthough fertility drugs stimulate ovulation and raise estradiol levels, their effect on breast cancer risk remains unresolved.MethodsAn extended follow-up was conducted among a cohort of 12,193 women evaluated for infertility bet…

Study questionDo fertility drugs influence the subsequent risk of endometrial cancer in a manner that is independent of other risk predictors, such as parity?Summary answerIn this follow-up of a large cohort of women evaluated for infertili…

ObjectiveTo examine the relationship of ovulation-inducing drugs and ovarian cancer.DesignRetrospective cohort study, with additional follow-up since initial report.SettingFive large reproductive endocrinology practices.Patient(s)In a retro…

BACKGROUND: Although studies have found elevated risks of certain cancers linked to infertility, the underlying reasons remain unclear. METHODS: In a retrospective cohort study of 12,193 U.S. women evaluated for infertility between 1965 and…

ObjectiveTo evaluate the risk of ovarian cancer as related to underlying causes of infertility.DesignRetrospective observational cohort study.SettingFive large reproductive endocrinology practices.Patient(s)A total of 12,193 women evaluated…

Gonadotropin-releasing hormone (GnRH) and its analogues have been extensively used in clinical medicine since they were identified and synthesized in 1971. Native GnRH stimulates gonadotrophs of the anterior pituitary and has been used for …

Wayne State University/Hutzel Hospital, Detroit, Michigan Correspondence: Kamran S. Moghissi, MD, Professor, Department of Obstetrics & Gynecology, Division of Reproductive Endocrinology & Infertility, Wayne State University/Hutzel Hospital…

OBJECTIVE: To determine whether hormone replacement therapy (HRT) plus goserelin (Zoladex) is as effective as goserelin alone for the relief of pelvic symptoms of endometriosis and to determine whether it reduces both the loss of bone miner…

A patient with long-standing secondary infertility was explored for myomectomy, at which time severe adenomyosis was found. A 6-month course of nafarelin acetate resulted in resolution of dysmenorrhea and uterine enlargement. The patient co…

Gonadotropin-releasing hormone (GnRH) agonists show promise as new therapeutic agents with considerable potential for clinical applications in endocrinology, gynecology, pediatrics, and oncology. GnRH agonists are derived from GnRH. This ar…

This study was designed to evaluate the effectiveness of three therapeutic modalities in the management of stage I and II endometriosis. Management modalities consisted of no treatment (controls, n = 56); oral medroxyprogesterone acetate (M…

Efficacy of oral medroxyprogesterone acetate (MPA) was assessed in 35 women with an established diagnosis of endometriosis (33 pelvic and 2 abdominal). MPA was given in a dosage of 30 mg daily for 90 days. Results indicated improvement or r…

In this study of 132 infertile couples, findings with hysterosalpingography (HSG) were compared with those observed at subsequent culdoscopy or laparoscopy. Both procedures correctly revealed normal tubes in 29% of the subjects and identica…