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OBJECTIVE: To develop and validate a prediction model for uterine fibroid risk based on clinical characteristics and blood biochemical indicators, and to explore its risk factors and clinical application value. METHODS: This retrospective c…

BACKGROUND: Deeply infiltrating endometriosis (DIE), characterized by its extrauterine invasion, is strongly associated with chronic pelvic pain (CPP). Peripheral-central sensitization synergistically contribute to the pathogenesis of CPP i…

PurposeThe growing antimicrobial resistance in Neisseria gonorrhoeae (N. gonorrhoeae) complicates the elimination of gonococcal infections and increases the risk of female infertility. In this study, we investigated the antimicrobial suscep…

The hypothalamus plays a vital role in reproductive processes. Previous studies have identified hypothalamic miRNAs involved in mammalian reproduction, but the miRNA profiles induced by photoperiod changes remain unclear. In this study, we …

BackgroundImplantation failure is the most common cause of pregnancy failure and is a major limiting factor in assisted reproduction. Plasma microRNA (miRNA) expression profiles show dynamic changes among individuals with successful implant…

Polycystic Ovary Syndrome (PCOS) is a complex endocrine disorder and a major cause of female infertility. While epigenetic dysregulation, notably DNA methylation, has been recognized as a key driver of PCOS pathogenesis, the specific involv…

Background and aimsMenstrual disorders are closely related to the disorder of gut microbiota. This study aims to explore the impact of Washed microbiota transplantation (WMT) on the quality of life, depression and anxiety scale scores, and …

Adenomyosis is an intractable gynecological disorder that can give rise to severe pelvic pain, heavy menstrual bleeding, and infertility, predominantly affecting women of reproductive age. The limited efficacy of current pharmacological int…

Although Müllerian adenosarcoma of the uterus shows weak malignant potential, there are still some factors indicating a worse prognosis. An incontinuous pelvic pain with urinary frequency, urgency, and hypouricemia arose in a mid-70s woman …

BackgroundHyperosmolal lubricants may negatively affect the vaginal microenvironment, increasing the risk for bacterial vaginosis (BV). We compared the incidence of Amsel-defined BV in reproductive-age women exposed to hyperosmolal lubrican…

ObjectivesLeiomyomatosis peritonealis disseminata (LPD) is a rare and specific type of leiomyomatosis that is often misdiagnosed as malignant tumor with peritoneal metastasis, and accurate diagnosis is critical to treatment planning. The pu…

BackgroundInfertility has become a global health concern, especially as the aging population continues to grow. Previous studies suggest that gut microbiota plays a crucial role in female reproductive health. This study aimed to investigate…

BackgroundChronic pain afflicts approximately 20% of the global adult population and is frequently undertreated, with available pharmacologic options often associated with significant long-term adverse effects. Although omega-3 fatty acids …

PURPOSE: The global prevalence and trends of gynecological diseases (GDs) among women of childbearing age (WCBA) remain unclear and may be underestimated. This study aims to evaluate the prevalence of GDs at global, regional, and national l…

BackgroundThis study aimed to assess the evolution, trends, and research hotspots of publications related to natural killer (NK) cells and miscarriage.MethodsThe literature on NK cells and miscarriage was retrieved from the Web of Science C…

BACKGROUND: Endometriosis is a chronic inflammatory condition afflicting women of reproductive age. Our study aims to clarify the function and mechanism of insulin-like growth factor 2 mRNA-binding protein 1 (IGF2BP1) and high mobility grou…

BackgroundHeart failure (HF) represents the terminal stage of various cardiovascular disorders, with immunogenic cell death (ICD) potentially influencing HF progression through modulation of immune cell activity. This study aimed to identif…

Zhixing Jin,1,* Yaoming Peng,2,* He Zhang,1 Xiaoping He,2 Yi Zhang,1 Xin Pan,1 Min Li,1 Qianqian Yang3 1Department of Obstetrics and Gynecology, The First Affiliated Hospital of Soochow University, Suzhou, Jiangsu, 215123, People’s Republic…

PURPOSE: To test the expression profile of transient receptor potential channels (TRPs) in adenomyosis patients and evaluate the effects of primidone on tamoxifen-induced adenomyosis mice. PATIENTS AND METHODS: This study included in vivo …

Endometriosis‑associated infertility is considered to be linked to cellular senescence. The present study assessed whether rapamycin, a senescence inhibitor, ameliorates endometriosis‑associated infertility by upregulating peroxisome prolif…

Prostaglandin E2 (PGE2) signaling through EP2 and EP4 receptors is crucial in regulating inflammation, pain, and cancer progression. While selective and dual antagonists for these receptors hold therapeutic potential, their binding mechanis…

PURPOSE: The study was designed to investigate whether estrogen regulates cell migration through cell polarity signaling and contributes to adenomyosis development. METHODS: In vitro study, Ishikawa cells received different treatments, Wes…

BackgroundTransumbilical laparoendoscopic single-site surgery (TU-LESS) has been widely used in multiple gynecological fields, but the report on its use during during pregnancy is limited. This study aimed to assess the safety and feasibili…

IntroductionChronic endometritis (CE) is a prolonged, mild inflammation of the endometrial lining. This study investigated the impact of the impact of antibiotic treatment combined with vaginal Lactobacillus on pregnancy outcomes in inferti…

BackgroundEvidence indicates that the risk of developing a secondary ovarian cancer (OC) is correlated with estrogen receptor (ER) status. However, the clinical significance of the relationship between ER-associated breast cancer (BC) and c…