Akiko Hasegawa
No ORCID on file
· 15 papers in corpus
· active 2007-2018
Study types
- article 14
- other 1
Condition tags
- endometriosis 14
- endometrioma 3
Top journals
Frequent coauthors
- Yutaka Osuga 14
- Osuga Y 12
- Hasegawa A 12
- Tetsuya Hirata 11
- Osamu Yoshino 11
- Yasushi Hirota 11
- Kaori Koga 10
- Miyuki Harada 10
- Yojiro Taketani 10
- Taketani Y 9
article
2018
article
2016
PROBLEM: Neutrophils are known to be accumulated in endometriosis; however, direct evidence of the impact of neutrophils in the development of endometriosis was lacking. To clarify the importance of neutrophils, we examined the effect of ne…
article
2015
ObjectiveTo investigate the in vitro effect of drospirenone on human eutopic endometrial (EuSC) and ectopic endometriotic stromal cells (EcSC).DesignComparative and laboratory study. The experimental procedures were approved by the Institut…
article
2015
article
2013
CONTEXT: Endometriosis is a chronic inflammatory disease in which immune response and production of estrogen in endometriotic tissues are involved in the development of the disease. Prostaglandin E2 (PGE2) stimulates aromatase (P450arom) ex…
article
2012
ObjectiveTo investigate a new role of interleukin (IL)-17A in endometriosis.DesignLaboratory study.SettingUniversity hospital.Patient(s)Patients with ovarian endometrioma undergoing laparoscopy or laparotomy.Intervention(s)Primary culture o…
article
2011
ObjectiveTo examine the effects of interleukin (IL)-17F on the secretion of IL-8 and the gene expression of cyclooxygenase 2 (COX2) in endometriotic stromal cells.DesignIn vitro experimental study using human samples.SettingUniversity hospi…
other
2010
In an animal endometriosis model, the administration of hyaluronic acid (HA) reagent significantly suppressed the formation of endometriotic lesions in both number and weight. This effect was found when HA treatment was conducted at the tim…
article
2009
Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases such as trypsin, tryptase, and coagulation factors VIIa and Xa. A large body of evidence has shown that PAR2 plays an important rol…
article
2008
Endometriosis is a common gynecological disease that affects approximately 10% of women of childbearing age. It is characterized by endometrial growth outside the uterus and often results in inflamed lesions, pain, and reduced fertility. Al…
article
2008
Several lines of evidence indicate that the Th2 immune response is associated with endometriosis. Although an increased concentration of interleukin (IL)-4, a typical Th2 cytokine, has been reported in endometriotic tissues, the implication…
article
2008
BACKGROUND: The increase in concentration of osteoprotegerin, an antagonist of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), in the peritoneal fluid of women with endometriosis may interfere with TRAIL-induced apoptosis i…
article
2007
The concentration of the soluble form of CD44, a competitive inhibitor for CD44 and hyaluronic acid binding, is higher in the peritoneal fluid of patients with endometriosis than in the peritoneal fluid of patients without endometriosis.
article
2007
IL-17A is secreted from Th17 cells, a discovery leading to revision of the mechanism underlying the role of Th1/Th2 in the immune response. Strong evidence suggests that immune responses associated with inflammation are involved in the path…
article
2007
CONTEXT: Metformin, a widely used treatment for diabetes that improves insulin sensitivity, also has both antiinflammatory properties and a modulatory effect on ovarian steroid production, two actions that have been suggested to be efficaci…