Hisashi Narahara

No ORCID on file · 63 papers in corpus
article 2009
Simvastatin inhibits the proliferation and the contractility of human endometriotic stromal cells: a promising agent for the treatment of endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2009.06.055

Simvastatin significantly inhibited the proliferation of endometriotic stromal cells, attenuated the collagen gel contraction mediated by these cells, and suppressed endometriotic stromal cell attachment to collagen fibers. Simvastatin is c…

article 2007
Collagen gel contractility is enhanced in human endometriotic stromal cells: a possible mechanism underlying the pathogenesis of endometriosis-associated fibrosis
Human Reproduction ·doi:10.1093/humrep/del485

BACKGROUND: Excessive fibrosis is frequently associated with endometriosis. To evaluate the involvement of the extracellular matrix contractility of endometriotic stromal cells (ECSCs) in the pathogenesis of endometriosis-associated fibrosi…

article 2007
The Role of Apoptotic Dysfunction in the Pathogenesis of Endometriosis
·doi:10.2174/1573404810703020113

Endometriosis, a disease affecting 3-10% of women of reproductive age, is characterized by the ectopic growth of endometrial tissue. Increasingly, endometriosis is also becoming recognized as a condition in which ectopic endometrial cells e…

article 2006
Application of the nuclear factor-κB inhibitor BAY 11-7085 for the treatment of endometriosis: an in vitro study
American journal of physiology. Endocrinology and metabolism ·doi:10.1152/ajpendo.00135.2006

Most of the current medical treatments for endometriosis aim to downregulate estrogen activity. However, a high recurrence rate after medical treatment has been the most significant problem. BAY 11-7085, a soluble inhibitor of NK-kappaB act…

article 2006
Hypoxia regulates vascular endothelial growth factor and soluble fms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts
·doi:10.1016/j.fertnstert.2005.10.023

ObjectiveTo evaluate the effect of hypoxia on the production of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in the human fallopian tube.DesignThe secretion of VEGF and sFlt-1 by cultured oviduct…

article 2006
Insulin-like Growth Factor-I Regulates Vascular Endothelial Growth Factor Secretion by Human Oviductal Epithelial Cells and Stromal Fibroblasts
·doi:10.1016/j.jsgi.2006.03.007

ObjectiveThe aim of the current study is to evaluate the effect of insulin-like growth factor-I (IGF-I) on the production of vascular endothelial growth factor (VEGF) in the human fallopian tube.MethodsHuman oviductal epithelial cells (OEC)…

article 2006
Interleukin-1β regulates vascular endothelial growth factor and solublefms-like tyrosine kinase-1 secretion by human oviductal epithelial cells and stromal fibroblasts
·doi:10.1080/08916930600929487

The aim of the present study was to evaluate the effects of interleukin (IL)-1beta on the production of vascular endothelial growth factor (VEGF) and soluble fms-like tyrosine kinase-1 (sFlt-1) in the human fallopian tube. Human oviductal e…

article 2006
β-Hydroxyisovalerylshikonin induces apoptosis and G0/G1 cell-cycle arrest of endometriotic stromal cells: a preliminary in vitro study
Human Reproduction ·doi:10.1093/humrep/del270

BACKGROUND: Most of the current medical treatments for endometriosis aim to down-regulate the estrogen activity. However, a high recurrence rate after medical treatments has been the most significant problem. Beta-hydroxyisovalerylshikonin …

article 2005
Bufalin induces apoptosis and the G0/G1 cell cycle arrest of endometriotic stromal cells: a promising agent for the treatment of endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gah249

Most of the current medical treatments for endometriosis aim to down-regulate the estrogen activity. However, a high recurrence rate after medical treatments has been the most significant problem. Bufalin is a major digoxin-like immunoreact…

article 2004
Differential effects of interferon-α and -β on the secretion of vascular endothelial growth factor by eutopic and ectopic endometrial stromal cells
·doi:10.1016/j.fertnstert.2004.03.029

Interferon (IFN)-beta, not IFN-alpha, suppresses vascular endothelial growth factor secretion in endometriotic cyst stromal cells. It was suggested that IFN-beta may be more suitable than IFN-alpha as an anti-endometriotic agent.

article 2004
Down-Regulation of Interleukin-1 Receptor Type 1 Expression Causes the Dysregulated Expression of CXC Chemokines in Endometriotic Stromal Cells: A Possible Mechanism for the Altered Immunological Functions in Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2004-0354

To evaluate the involvement of chemokines in the pathogenesis of endometriosis, we investigated the expression of CXC chemokines in cultured ovarian endometriotic cyst stromal cells (ECSC), endometrial stromal cells with endometriosis (ESCw…

article 2003
The clinical role of interleukin-6 and interleukin-6 soluble receptor in human follicular fluids
·doi:10.1007/s102380300012

In order to investigate the role of interleukin-6 (IL-6) and interleukin-6 soluble receptor (sR) in human ovulation, we evaluated the concentrations in human follicular fluid and analyzed the correlation of IL-6 and IL-6 sR with oocyte matu…

article 2000
Platelet-activating factor-induced intracellular calcium waves in human uterine myometrial cells
·doi:10.1016/s0301-2115(00)00293-1

ObjectiveWe visualized and investigated the intracellular calcium waves propagated by platelet-activating factor (PAF) in cultured human myometrial cells.Study designMyometrial cells were stimulated with PAF ranging between 10(-8) and 10(-1…