Platelet-activating factor-induced intracellular calcium waves in human uterine myometrial cells

Yasuko Yoshimatsu, Jun Yoshimatsu, Hisashi Narahara, Aiko Yasuda, Isao Miyakawa
In: European Journal of Obstetrics & Gynecology and Reproductive Biology · 2000 · vol. 93(2) , pp. 147–150 · doi:10.1016/s0301-2115(00)00293-1 · PMID:11074135 · W2132717952
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This paper investigated the role of platelet-activating factor in initiating intracellular calcium waves within human uterine myometrial cells.

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Abstract

ObjectiveWe visualized and investigated the intracellular calcium waves propagated by platelet-activating factor (PAF) in cultured human myometrial cells.Study designMyometrial cells were stimulated with PAF ranging between 10(-8) and 10(-15) M. For the observation of calcium waves, calcium green-1 and a confocal laser microscopy were used. Cells were also stimulated with 10(-9) M of PAF in a calcium-free solution.ResultsIn physiological solution, PAF at concentrations ranging between 10(-9) and 10(-15) M induced intracellular calcium waves. Mean wave speed was 16.1+/-5.6 microm/s. Wave speeds were independent of the PAF concentration. Similar results were observed in the absence of added calcium, with the exception that the wave speeds were significantly slower (7.3+/-3.3 microm/s). CONCLUSIONS This is the first study to demonstrate the calcium waves propagated by PAF stimulation in human myometrial cells. These observations further support the proposed role of PAF in parturition.

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