The clinical role of interleukin-6 and interleukin-6 soluble receptor in human follicular fluids

Fumiko Kawasaki, Yasushi Kawano, Zeshan Hasan, Hisashi Narahara, Isao Miyakawa
In: Clinical and Experimental Medicine · 2003 · vol. 3(1) , pp. 27–31 · doi:10.1007/s102380300012 · PMID:12748876 · W1971928811
article OA: closed CC0 ⤵ 2 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-09 ⓘ

This study found higher concentrations of IL-6 and IL-6 sR in follicular fluid with mature oocytes, suggesting their role in human ovulation and potential value as maturation markers.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 ⓘ

This study measured interleukin-6 (IL-6) and IL-6 soluble receptor (sR) concentrations in human follicular fluid from 45 women undergoing in vitro fertilization and embryo transfer, and assessed associations with oocyte maturation. Using ELISA, the authors found IL-6 levels were significantly higher in follicular fluid than serum, while IL-6 sR levels were significantly lower; both IL-6 and IL-6 sR were higher in follicular fluid containing mature oocytes than immature oocytes. In cultured granulosa cells from follicular fluid, IL-6 production increased markedly after forskolin (24 h) and after longer treatment (48 h), suggesting cAMP-related regulation. The paper explicitly links its findings to preovulatory follicular growth and notes the potential marker value, but it does not state a causal role for IL-6 in ovulation beyond these associations. This paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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