Paolo Vercellini

OBJECTIVE: To synthesize the available evidence on abdominal wall endometriosis (AWE) after cesarean section (CS) by characterizing its clinical features and timing of presentation, and to determine how often prior or concomitant endometrio…

Neonatal uterine bleeding (NUB) has been hypothesized as a relatively common early-life event potentially linked to the later development of endometriosis through retrograde menstruation. However, its true prevalence and biological nature r…

UNLABELLED: Introduction: In recent years, dietary supplements have emerged as popular "natural" alternatives to conventional pharmacological treatments for various conditions, including endometriosis. The growing popularity of supplements …

OBJECTIVES: Endometriosis and endometrial polyps are both estrogen-dependent conditions, and an association between these two pathologies has been observed in infertile women. Our research question was: "Is there an association between endo…

Endometriosis, particularly ovarian endometrioma, is associated with a 2-fold increased risk of ovarian cancer (OC), especially the clear cell and endometrioid subtypes. However, the absolute lifetime risk of OC in women with endometriosis …

RESEARCH QUESTION: Can transvaginal ultrasonography (TVUS) reliably detect and quantify free pelvic fluid (FPF) as a surrogate marker of retrograde menstruation, and how do its volume and characteristics vary across menstrual phases, charac…

STUDY QUESTION: Are there histological and immunohistochemical patterns of superficial peritoneal endometriotic lesions of symptomatic patients that characterize non-response to dienogest treatment and may suggest progesterone resistance? …

INTRODUCTION: Women with endometriosis frequently experience psychological and sexual concerns. Combined oral contraceptives (COCs) and progestin-only pills (POPs) represent first-line treatments for the disease, yet their potential negativ…

The link between endometriosis and other medical conditions is gaining attention. Such insights could enhance clinical approaches to manage the disease and potentially reveal new, unrecognized mechanisms of its development. The aim of this …

Whether endometriosis is a progressive disease remains debated. Central to this debate is understanding the natural history of endometriotic lesions, which are essentially wounds undergoing repeated tissue injury and repair. Viewing the dis…

STUDY QUESTION: Are endometriotic lesions affecting bilateral organs or anatomical structures distributed symmetrically on both sides of the body? SUMMARY ANSWER: The left-sided preponderance of pelvic endometriotic lesions, and the right-…

Endometriosis is associated with nociceptive pain and with peripheral as well as central sensitization. To relieve nociceptive pain, most symptomatic patients benefits from hormonal therapy, which includes first-line (progestogens and estro…

Endometriosis is associated with nociceptive pain, as well as peripheral and central sensitization. Evidence-based treatment suggestions for controlling endometriosis should be based on the convergence of the best scientific evidence, physi…

BACKGROUND: Symptoms of endometriosis often emerge during adolescence and intensify in early adulthood, critical periods for educational and career development. However, evidence on its impact on women’s broader life trajectories, particula…

Background/Objectives: The scientific community is still divided between supporters of the implantation theory and researchers who advocate the theory of coelomic metaplasia/embryonic cell remnants to explain the initiation of endometriosis…

OBJECTIVES: Vulvar lichen sclerosus (VLS) is a chronic condition. If untreated, it may lead to anatomical modifications, including introital stenosis, which may impact sexual function and quality of life. First line treatment with topical c…

Endometriosis can impair natural reproduction through multiple mechanisms, including distortion of pelvic anatomy and chronic peritoneal inflammation. On this basis, surgical treatment might be reasonably expected to benefit. However, clini…

Recent research has proven that peripheral (PS) and central sensitization (CS), mental health, and myofascial dysfunction all play a role, alongside nociception, in the genesis and in the perpetuation of endometriosis' symptoms. However, su…

Across studies, the percentage of individuals reporting regularly engaging in menstrual coitus ranges between 4% and 43%. Although no clinical guideline recommends avoiding sexual activity during menstruation, according to some researchers …