Akiko Hasegawa

No ORCID on file · 15 papers in corpus · active 2007-2018

Study types

  • article 14
  • other 1

Condition tags

  • endometriosis 14
  • endometrioma 3
article 2018
CD73 as a candidate glycoprotein for a target of a mouse anti-sperm auto-monoclonal antibody, Ts4, which recognizes a bisecting GlcNAc structure in the testicular germ cells
·doi:10.1016/j.jri.2018.09.027
article 2016
Neutrophil depletion reduces endometriotic lesion formation in mice
American journal of reproductive immunology (New York, N.Y. : 1989) ·doi:10.1111/aji.12540

PROBLEM: Neutrophils are known to be accumulated in endometriosis; however, direct evidence of the impact of neutrophils in the development of endometriosis was lacking. To clarify the importance of neutrophils, we examined the effect of ne…

article 2015
Drospirenone induces decidualization in human eutopic endometrial stromal cells and reduces DNA synthesis of human endometriotic stromal cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.03.023
article 2015
The expression and the role of bradykinin (BK) receptor in endometriosis
·doi:10.1016/j.jri.2015.09.014
article 2013
Interleukin-4 and Prostaglandin E2 Synergistically Up-Regulate 3β-Hydroxysteroid Dehydrogenase Type 2 in Endometrioma Stromal Cells
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2012-3475

CONTEXT: Endometriosis is a chronic inflammatory disease in which immune response and production of estrogen in endometriotic tissues are involved in the development of the disease. Prostaglandin E2 (PGE2) stimulates aromatase (P450arom) ex…

article 2012
Interleukin-17A is present in neutrophils in endometrioma and stimulates the secretion of growth-regulated oncogene–α (Gro-α) from endometrioma stromal cells
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.07.1117
article 2011
Interleukin-17F increases the secretion of interleukin-8 and the expression of cyclooxygenase 2 in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.04.060
other 2010
Hyaluronic acid reagent suppressed endometriotic lesion formation in a mouse model
Fertility and sterility ·doi:10.1016/j.fertnstert.2010.02.053

In an animal endometriosis model, the administration of hyaluronic acid (HA) reagent significantly suppressed the formation of endometriotic lesions in both number and weight. This effect was found when HA treatment was conducted at the tim…

article 2009
TGF-Beta Increases Proteinase-Activated Receptor 2 (PAR2) Expression and Upregulates PAR2 Activation-Induced Secretion of IL-6 and IL-8 in Endometriotic Stromal Cells.
·doi:10.1093/biolreprod/81.s1.151

Proteinase-activated receptor 2 (PAR2) is a G protein-coupled receptor that is activated by serine proteases such as trypsin, tryptase, and coagulation factors VIIa and Xa. A large body of evidence has shown that PAR2 plays an important rol…

article 2008
Deficiency of Immunophilin FKBP52 Promotes Endometriosis
The American journal of pathology ·doi:10.2353/ajpath.2008.080527
article 2008
Interleukin-4 Stimulates Proliferation of Endometriotic Stromal Cells
The American journal of pathology ·doi:10.2353/ajpath.2008.071044
article 2008
Tunicamycin enhances the apoptosis induced by tumor necrosis factor-related apoptosis-inducing ligand in endometriotic stromal cells
Human Reproduction ·doi:10.1093/humrep/den385

BACKGROUND: The increase in concentration of osteoprotegerin, an antagonist of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL), in the peritoneal fluid of women with endometriosis may interfere with TRAIL-induced apoptosis i…

article 2007
High soluble CD44 concentration in peritoneal fluid in endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2007.05.051
article 2007
Interleukin (IL)-17A Stimulates IL-8 Secretion, Cyclooxygensase-2 Expression, and Cell Proliferation of Endometriotic Stromal Cells
Endocrinology ·doi:10.1210/en.2007-0749

IL-17A is secreted from Th17 cells, a discovery leading to revision of the mechanism underlying the role of Th1/Th2 in the immune response. Strong evidence suggests that immune responses associated with inflammation are involved in the path…

article 2007
Metformin Suppresses Interleukin (IL)-1β-Induced IL-8 Production, Aromatase Activation, and Proliferation of Endometriotic Stromal Cells
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2006-2486

CONTEXT: Metformin, a widely used treatment for diabetes that improves insulin sensitivity, also has both antiinflammatory properties and a modulatory effect on ovarian steroid production, two actions that have been suggested to be efficaci…