Ling S

No ORCID on file · 9 papers in corpus · active 2023-2025

Study types

  • article 2
  • other 2
  • preprint 1

Condition tags

  • endometriosis 4
  • infertility 2
  • adenomyosis 2
  • dysmenorrhea 1
2025
Association between mitochondrial SIRTs (SIRT3, SIRT4, and SIRT5) and PCOS.
European journal of medical research ·doi:10.1186/s40001-025-02862-3

Polycystic ovary syndrome (PCOS) is a complex endocrine and metabolic disorder with unclear pathogenesis. Increasing evidence suggests that oxidative stress and mitochondrial dysfunction contribute to PCOS development. Sirtuins (SIRTs), esp…

other 2025
Identification of EPHB4 as a potential causal gene and therapeutic target for endometriosis using Mendelian randomization
Hereditas ·doi:10.1186/s41065-025-00457-w

OBJECTIVES: Endometriosis is a common condition among women, characterized by chronic pain and infertility, presenting significant challenges for clinicians. This study aims to identify potential druggable targets to offer new therapeutic a…

preprint 2025
Plasma Trimethylamine N-Oxide as a Non-Invasive Biomarker for Adenomyosis: A Cross-Sectional Study
·doi:10.22541/au.175439363.37991172/v1

Objective To identify novel and noninvasive biomarkers for the diagnosis of adenomyosis and to provide potential therapeutic targets. Design We conducted a cross-sectional study using data from 110 women of reproductive age who underwent pe…

2025
Proanthocyanidins delaying the premature ovarian insufficiency through regulatory sirt1-p53-p21 signaling pathway in female germline stem cells.
Journal of ovarian research ·doi:10.1186/s13048-025-01661-y

BackgroundAs women age, their ovarian follicle pool naturally declines. However, female germline stem cells (FGSCs) possess a unique ability to differentiate into oocytes and continuously self-renew, providing an effective means of delaying…

article 2025
WISP2/CCN5 revealed as a potential diagnostic biomarker for endometriosis based on machine learning and single-cell transcriptomic analysis
Functional & integrative genomics ·doi:10.1007/s10142-025-01631-z

OBJECTIVE: Endometriosis is a prevalent gynecological disease characterized by the ectopic growth of functional endometrial tissue outside the uterine cavity, affecting millions of women worldwide. Currently, the definitive diagnosis relies…

other 2024
Efficacy of hysteroscopic levonorgestrel‑releasing intrauterine device fixation in the treatment of adenomyosis: A cohort study
Biomedical reports ·doi:10.3892/br.2024.1797

The present study aimed to investigate the efficacy of hysteroscopic levonorgestrel-releasing intrauterine device (LNG-IUD) fixation surgery in the treatment of adenomyosis through a cohort study. The cohort study was performed at the Affil…

article 2024
Epidemiologic and genetic associations of female reproductive disorders with depression or dysthymia: a Mendelian randomization study
Scientific reports ·doi:10.1038/s41598-024-55993-8

Observational studies have previously reported an association between depression and certain female reproductive disorders. However, the causal relationships between depression and different types of female reproductive disorders remain unc…

2024
Genetic Prediction of Osteoporosis by Anti-Müllerian Hormone Levels and Reproductive Factors in Women: A Mendelian Randomization Study.
Calcified tissue international ·doi:10.1007/s00223-024-01220-5

Previous observational studies have suggested that anti-Müllerian hormone (AMH) and reproductive factors are linked to reduced bone mineral density (BMD) and an increased risk of osteoporosis (OP) in women. However, related studies are limi…

2023
Chito-oligosaccharides and macrophages have synergistic effects on improving ovarian stem cells function by regulating inflammatory factors.
Journal of ovarian research ·doi:10.1186/s13048-023-01143-z

BackgroundChronic low-grade inflammation and ovarian germline stem cells (OGSCs) aging are important reasons for the decline of ovarian reserve function, resulting in ovarian aging and infertility. Regulation of chronic inflammation is expe…