Zhang L

Endometriosis is marked by the ectopic growth, spread, and invasion of endometrial tissue beyond the uterus, resulting in recurrent bleeding, pain, reproductive challenges, and the formation of nodules or masses. Despite advancements in det…

ObjectiveThis study aims to evaluate the role of MRI-guided hysteroscopic one-step precise resection in diagnosing suspected myometrial invasion (MI) of endometrial cancer (EC) in patients desiring fertility preservation and to analyze the …

OBJECTIVE: The aim of the present retrospective cohort study was to compare the clinical characteristics, perioperative outcomes and pregnancy outcomes of laparo-endoscopic single-site (LESS) surgery, conventional laparoscopy (CL) surgery a…

PurposeARID1A, encoding a component of the switch/sucrose nonfermentable complex, is frequently mutated in urothelial carcinoma. However, its specific impacts on clinical outcomes and CD8+ T-cell functions in urothelial carcinoma remain poo…

The relationship between hyperprolactinemia and gut microbiota remains unclear at present. This study employs a Mendelian randomization (MR) approach to assess the potential causal links between gut microbiota and the incidence of hyperprol…

A good quality egg is essential for a successful pregnancy and early embryo development. Oocyte development is vulnerable to environmental exposures. Bisphenol S (BPS) is widely used as a replacement for its analog bisphenol A, but the repr…

BACKGROUND: Uterine fibroids and endometriosis are common benign gynecological diseases affecting the health of women of childbearing age, characterized by high incidence and recurrence rates. Despite the increasing global emphasis on women…

BACKGROUND: The causal bridge from environmental exposure to endometriosis (Ems) biology remains incompletely defined. Di(2-ethylhexyl) phthalate (DEHP) is repeatedly implicated in elevated Ems risk, yet actionable molecular anchors linking…

BACKGROUND: Spironolactone, eplerenone, and finerenone are three commonly used mineralocorticoid receptor antagonists (MRAs) with cardioprotective and renoprotective effects. However, comparative real-world safety evaluations remain limited…

CXC chemokine receptor 3 (CXCR3) is a G protein-coupled chemokine receptor that plays a key role in regulating immune responses and is involved in various pathological processes, particularly in tumor development and inflammatory diseases, …

BACKGROUND: Researchers have explored machine learning (ML) in diagnosing endometriosis. However, systematic evidence on its diagnostic accuracy for endometriosis remains scarce. OBJECTIVE: To systematically review the performance of machi…

Goserelin is widely used for prostate cancer, but drug-induced liver injury (DILI) has been rarely reported. We present a patient who developed ALT/AST elevations after each subcutaneous injection, followed by improvement after withdrawal a…

Previous studies show that orphan nuclear receptor 4A1 (NR4A1) regulates endometriotic cell growth, survival, estrogen receptor β (ERβ), mechanistic target of rapamycin signaling and fibrosis. NR4A2 is also expressed in epithelial and strom…

The incidence of malignant tumors continues to grow. Still, with the rapid development of various diagnostic and therapeutic techniques, the survival rate of malignant tumors has been improved, and the increased survival rate has introduced…

BackgroundOvarian sex cord-stromal tumors (OSCSTs) are a rare and heterogeneous group of ovarian neoplasms, encompassing various subtypes such as ovarian thecoma, fibroma (including cellular fibroma), and ovarian granulosa cell tumors (OGCT…

BackgroundRobotic liver resections (RLRs) are increasingly performed worldwide. The IWATE criteria offer a standardized classification to correlate the complexity of these procedures with surgical outcomes. This study analyzes a single surg…

Objective: To analysis the safety and feasibility of laparoscopic total hysterectomy in patients with obliterated rectouterine pouch. Methods: A retrospective analysis was conducted on 197 patients who underwent laparoscopic total hysterect…

Ovarian cancer (OC) is a deadly disease and lacks a precise marker for diagnosis worldwide. Our previous work has shown the overexpression of flotillin-1 (FLOT1) in OC tissue. To improve diagnostic sensitivity and accuracy, we evaluated the…

BackgroundGasless transvaginal natural orifice transluminal endoscopic surgery (G-vNOTES) can avoid complications related to pneumoperitoneum, but there is limited research on G-vNOTES. Here, we aimed to compare the hemodynamic profiles and…

PURPOSE: Ovarian endometriosis, a prevalent condition in reproductive-age women, causes dysmenorrhea and infertility, significantly impairing quality of life. To date, there is no systematic description of ovarian endometriosis in the liter…

Xian Wu,1,* Xia Yu,2,* Lu Yang,1,* Aijie Xie,1 Yunyi Su,1 Ling Zhang,1 Yonghong Lin,1 Xiaoqin Gan1 1Department of Obstetrics and Gynecology, Chengdu Women’s and Children’s Central Hospital, School of Medicine, University of Elec…

BackgroundDysmenorrhea is a prevalent gynecological disorder with multifactorial pathophysiology, including prostaglandin overproduction, inflammation, and pain sensitization. Emerging evidence suggests that gut microbiota may contribute to…

Abstract Introduction Endometriosis (EMS) is an estrogen-dependent inflammatory disorder characterized by immune dysregulation. This condition profoundly affects the quality of life and reproductive health of nearly 200 million women of rep…

BackgroundChat-Generative Pretrained Transformer (ChatGPT) has proven its value in medical information acquisition and perioperative education. This study aimed to evaluate correlated factors to explore the value of ChatGPT in patient commu…

Endometriosis is one of the most common, difficult, and complicated gynecological disorders. The present study investigated the expression of HOXC6 in endometriosis and described its possible role in its pathogenesis. Ectopic and eutopic en…