Olivier Donnez

No ORCID on file · 50 papers in corpus · active 1997-2025

Study types

  • article 29
  • review 10
  • other 7
  • letter 2
  • editorial 1

Condition tags

  • endometriosis 36
  • infertility 9
  • adenomyosis 9
  • dyspareunia 6
  • dysmenorrhea 5
  • chronic_pelvic_pain 4
  • endometrioma 3
  • bowel_endometriosis 2
other 2025
Isthmocele-fix it or observe, an ongoing dilemma
Fertility and sterility ·doi:10.1016/j.fertnstert.2025.03.007
rct 2024
Linzagolix therapy versus a placebo in patients with endometriosis-associated pain: a prospective, randomized, double-blind, Phase 3 study (EDELWEISS 3)
Human Reproduction ·doi:10.1093/humrep/deae076

STUDY QUESTION: Does linzagolix administered orally once daily for up to 3 months at a dose of 75 mg alone or 200 mg in combination with add-back therapy (ABT) (1.0 mg estradiol; 0.5 mg norethindrone acetate, also known as norethisterone ac…

review 2023
Cesarean scar disorder: Management and repair
Best practice & research. Clinical obstetrics & gynaecology ·doi:10.1016/j.bpobgyn.2023.102398

Cesarean scar disorder (CSD) is an entity recently defined as uterine niche with at least one primary or 2 secondary symptoms. CSDs can be visualized by hysterosalpingography, transvaginal sonography, saline infusion sonohysterography, hyst…

letter 2023
Evolution of uterine adenomyosis volume during and after GnRH antagonist (linzagolix) treatment: lessons for further clinical trials
Fertility and sterility ·doi:10.1016/j.fertnstert.2023.07.012
article 2023
L’endométriose digestive, une forme d’endométriose profonde
·doi:10.1016/j.aidsoi.2023.07.004
other 2022
Treatment of symptomatic uterine adenomyosis with linzagolix, an oral gonadotrophin-releasing hormone antagonist: a pilot study
Reproductive biomedicine online ·doi:10.1016/j.rbmo.2021.09.019

RESEARCH QUESTION: Does a once-daily regimen of linzagolix, a new oral gonadotrophin-releasing hormone (GnRH) antagonist, given at a fully suppressive dose (200 mg) for 12 weeks, followed by a partially suppressive dose (100 mg) for a furth…

review 2021
Conservative Management of Rectovaginal Deep Endometriosis: Shaving Should Be Considered as the Primary Surgical Approach in a High Majority of Cases
Journal of clinical medicine ·doi:10.3390/jcm10215183

Deep endometriosis infiltrating the rectum remains a challenging situation to manage, and it is even more important when ureters and pelvic nerves are also infiltrated. Removal of deep rectovaginal endometriosis is mandatory in case of symp…

article 2021
EFFICACY AND SAFETY OF LINZAGOLIX FOR THE TREATMENT OF SEVERE ADENOMYOSIS: FINAL Results FROM A PILOT STUDY
·doi:10.1016/j.fertnstert.2021.07.881
letter 2021
Endometriosis and spontaneous hemoperitoneum in pregnancy: ab uno disce omnes… Is it always true?
Fertility and sterility ·doi:10.1016/j.fertnstert.2021.01.038
article 2021
P–299 Efficacy and safety of linzagolix for the treatment of severe adenomyosis: Initial results from a pilot study
·doi:10.1093/humrep/deab130.298

Abstract Study question Is a once daily regimen of the GnRH antagonist, linzagolix, high-dose (200mg) for 12 weeks then low-dose (100mg) for 12 weeks, effective in severe adenomyosis? Summary answer After 12 weeks, there was marked shrinkag…

article 2021
Uterine Adenomyosis Treated by Linzagolix, an Oral Gonadotropin-Releasing Hormone Receptor Antagonist: A Pilot Study with a New ’Hit Hard First and then Maintain’ Regimen of Administration
Journal of clinical medicine ·doi:10.3390/jcm10245794

(1) Background: The aim of the present pilot study was to study the effect of a new oral gonadotropin-releasing hormone antagonist on adenomyosis. (2) Methods: Eight premenopausal women, aged between 37 and 45 years, presenting with heavy m…

review 2020
Deep endometriosis: The place of laparoscopic shaving
Best practice & research. Clinical obstetrics & gynaecology ·doi:10.1016/j.bpobgyn.2020.05.006
article 2020
Gonadotropin-releasing hormone antagonist (linzagolix): a new therapy for uterine adenomyosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2020.04.017
article 2018
Introduction
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.01.035
article 2018
Invasion of human deep nodular endometriotic lesions is associated with collective cell migration and nerve development
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.08.016
editorial 2018
Ovarian endometriosis and infertility: in vitro fertilization (IVF) or surgery as the first approach?
Fertility and sterility ·doi:10.1016/j.fertnstert.2018.10.003
review 2018
Pathogenesis of uterine adenomyosis: invagination or metaplasia?
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.12.030
article 2018
Table of Contents
·doi:10.1016/s0015-0282(18)30247-4
review 2017
Choosing the right surgical technique for deep endometriosis: shaving, disc excision, or bowel resection?
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.09.006

Deep endometriosis (DE) remains the most difficult endometriotic entity to treat. Medical treatment for DE can reduce symptoms but does not cure the disease, and surgical removal of the lesion is required when lesions are symptomatic, impai…

other 2017
Gynecological and obstetrical outcomes after laparoscopic repair of a cesarean scar defect in a series of 38 women
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.09.033

OBJECTIVE: To evaluate gynecological and obstetrical outcomes, as well as remaining myometrial thickness, after laparoscopic repair of a cesarean scar. DESIGN: Observational study and prospective evaluation of the remaining myometrium befo…

article 2017
Important role of collective cell migration and nerve fiber density in the development of deep nodular endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2017.01.005
review 2016
Endometriosis and infertility
Panminerva medica

Endometriosis remains a very enigmatic and perplexing disease. The exact mechanism by which endometriosis causes infertility is still unclear. In the present paper, we will review possible mechanisms leading to subfertility or infertility i…

review 2016
Oxidative stress in the pelvic cavity and its role in the pathogenesis of endometriosis
Fertility and sterility ·doi:10.1016/j.fertnstert.2016.07.1075
article 2015
Invasion process of induced deep nodular endometriosis in an experimental baboon model: similarities with collective cell migration?
Fertility and sterility ·doi:10.1016/j.fertnstert.2015.05.011
article 2014
Enhanced follicular recruitment and atresia in cortex derived from ovaries with endometriomas
Fertility and sterility ·doi:10.1016/j.fertnstert.2013.12.049