Kiyoshi Mizuguchi

No ORCID on file · 6 papers in corpus · active 2007-2012

Study types

  • article 5
  • review 1

Condition tags

  • endometriosis 3
article 2012
Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E2 production in human endometriotic stromal cells in spheroid culture
Fertility and sterility ·doi:10.1016/j.fertnstert.2011.11.005
article 2010
Dienogest, a synthetic progestin, inhibits prostaglandin E2 production and aromatase expression by human endometrial epithelial cells in a spheroid culture system
Steroids ·doi:10.1016/j.steroids.2010.08.010
article 2009
Dienogest, a synthetic progestin, inhibits the proliferation of immortalized human endometrial epithelial cells with suppression of cyclin D1 gene expression
Molecular human reproduction ·doi:10.1093/molehr/gap042

Dienogest is a specific progesterone receptor agonist with potent oral endometrial activity and is used in the treatment of endometriosis. In this study, we examined the direct effects of dienogest on the proliferation of human endometrial …

review 2009
Pharmacological and clinical profile of dienogest (DINAGEST Tab. 1 mg)
Nihon yakurigaku zasshi. Folia pharmacologica Japonica ·doi:10.1254/fpj.133.32

ジエノゲスト（販売名：ディナゲスト錠1 mg）は，プロゲステロン受容体に対して選択的なアゴニスト活性を示す第4世代のプロゲスチンである．ジエノゲストは，ラットおよびウサギに経口投与することによりプロゲステロン作用を示し，一方，アンドロゲン作用，グルココルチコイド作用およびミネラルコルチコイド作用は示さなかった．ジエノゲストは，カニクイザルに反復経口投与することにより月経周期の停止，月経周期に伴う血中エストラジオール濃度の上昇および黄体形成ホルモン濃度の上昇を抑制し，卵巣機能抑…

article 2008
Dienogest, a selective progestin, reduces plasma estradiol level through induction of apoptosis of granulosa cells in the ovarian dominant follicle without follicle-stimulating hormone suppression in monkeys
·doi:10.1007/bf03345616
article 2007
Dienogest is a selective progesterone receptor agonist in transactivation analysis with potent oral endometrial activity due to its efficient pharmacokinetic profile
·doi:10.1016/j.steroids.2007.10.003