Sherry E. Rier

We investigated the ability of interleukin 6 (IL-6) to modulate human endometrial stromal cell growth in vitro. Stromal cell proliferation in response to treatment with varying concentrations of IL-6 was determined. Endo-metrial tissue was …

Endometriosis is a common gynecologic problem of unknown etiology. Estrogen dependence and immune modulation are established features of this disease, and environmental contaminants have been suggested to play a role in the pathobiology of …

Endometriosis is a common gynecologic problem of unknown etiology. Estrogen dependence and immune modulation are established features of this disease and recently environmental contaminants have been suggested to play a role in the pathobio…

Humans and animals are exposed daily to a complex mixture of polyhalogenated aromatic hydrocarbons (PHAHs). Previous work has shown that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with a dose-dependent increase in …

Humans and animals are exposed daily to a complex mixture of polyhalogenated aromatic hydrocarbons (PHAHs). Previous work has shown that exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) is associated with a dose-dependent increase in …

Environmental contaminants that are known to disrupt steroid action can influence the development of reproductive diseases. Our group has focused on whether 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD or dioxin) can disrupt steroid regulation…

BACKGROUND: A retrospective analysis was conducted on necropsy records from a large rhesus monkey colony to evaluate the age-related prevalence of endometriosis. METHODS: A total of 314 records collected over a 15-year period were analyzed,…

Endometriosis is classically defined as the growth of endometrial cells at sites outside the uterus. It is a common disease characterized by infertility, chronic pain and adhesion formation. Immune dysregulation, evidenced by decreased clea…

Endometriosis (EM) is characterized by the aberrant growth of endometrial cells at sites outside the uterus. We showed previously that peritoneal leukocyte interleukin-6 (IL-6) production is altered in women with EM relative to that in norm…

Endometriosis is a reproductive disease characterized by the growth of endometrial cells at sites outside the uterus. This disease is a serious disorder associated with chronic pain and infertility, which may be present in 6 million women i…

Endometriosis is a reproductive disease characterized by the growth of endometrial cells at sites outside the uterus.This disease is a serious disorder associated with chronic pain and infertility, which may be present in 6 million women in…

We investigated the ability of interleukin 6 (IL-6) to modulate human endometrial stromal cell growth in vitro. Stromal cell proliferation in response to treatment with varying concentrations of IL-6 was determined. Endometrial tissue was o…

The incidence of the reproductive disease endometriosis was determined in a colony of rhesus monkeys chronically exposed to 2,3,7,8-tetrachlorodibenzo-/?-dioxin (TCDD or dioxin) for a period of 4 years. Ten years after termination of dioxin…