Yan H

Jichan Nie,* Han Yan,* Wei Jiang Department of Gynecology, Obstetrics & Gynecology Hospital of Fudan University, Shanghai Key Laboratory of Reproduction and Development, Shanghai Key Laboratory of Female Reproductive Endocrine Relat…

BACKGROUND: Recurrence of endometrioma and dysmenorrhea after surgery remains a major clinical challenge. Identifying reliable risk factors is essential to optimize individualized treatment and follow-up strategies. However, large-scale dat…

BACKGROUND: The aim of this study was to compare two levonorgestrel-releasing intrauterine system fixation methods for the treatment of adenomyosis. METHODS: The study included patients with adenomyosis who underwent anchoring of the LNG-IU…

IMPORTANCE: Endometriosis, a chronic inflammatory condition affecting 10% of reproductive-aged individuals, remains underdiagnosed and poorly managed due to a limited understanding of its pathogenesis. Emerging evidence highlights the gut a…

BACKGROUND: Spontaneous ovarian endometrioma rupture typically presents with acute abdominal pain, a condition often complicated by tissue edema and pelvic adhesions that increase surgical difficulty. This study aims to evaluate the impact …

Phthalate esters (PAEs) and organophosphate esters (OPEs) are pervasive 20 environmental pollutants with endocrine-disrupting properties. Despite growing 21 evidence linking PAE/OPE exposure to female reproductive disorders, the 22 diseases…

Endometriosis is a chronic estrogen-dependent disorder affecting up to 10% of women of reproductive age, and the absence of reliable noninvasive diagnostic tools contributes to delayed diagnosis and disease progression. To identify potentia…

Alternative splicing (AS) plays a crucial role in various diseases, yet its functional significance in endometriosis remains poorly understood. In this study, we analyzed RNA-seq data from 146 endometriosis patients and 114 control endometr…

BackgroundOvarian and endometrial cancers together account for nearly 10% of all female cancer-related deaths worldwide, with ovarian cancer being the deadliest gynecologic malignancy. We aimed to evaluate the diagnostic performance of gene…

Diffuse uterine leiomyomatosis is frequently misdiagnosed, highlighting the need to improve awareness and understanding of this rare condition. We report a case of a 29-year-old nulliparous woman presenting with menorrhagia who was diagnose…

The JAK-STAT signaling pathway serves as a central regulator of diverse cellular processes encompassing proliferation, apoptosis, inflammation, and differentiation. Specifically, extracellular ligands such as interleukins, and colony-stimul…

BACKGROUND: Previous studies have suggested that aging may influence reproductive functions of female. Nonetheless, the causal relationship between aging and endometriosis has yet to be completely understood. OBJECTIVE: This study aims to …

Limei Chen,1,* Han Yan,2,* Jichan Nie2 1Hysteroscoy Center, Shanghai Obstetrics and Gynecology Hospital, Fudan University, Shanghai, 200011, People’s Republic of China; 2Department of General Gynecology, Shanghai Obstetrics and Gynecology H…

OBJECTIVE: To investigate the clinical features of bladder endometriosis and factors associated with urinary symptoms, pregnancy outcomes, and long-term effects of symptom relief and recurrence. DESIGN: A single-center retrospective cohort…

BackgroundMüllerian adenosarcoma (MA) is a rare low-grade malignant tumor. It is characterized by benign glandular epithelium and malignant sarcomatous stromal components. This tumor commonly arises in the uterine corpus. Primary ovarian MA…

CapsuleThe gestational age at fetal reduction had no effect on pregnancy outcome when reduction was performed before 17 + 4 weeks. After 17 + 4 weeks, the later the fetal reduction was done, the earlier the delivery and lower the birthweigh…

BACKGROUND: Rectal endometriosis is a complex condition requiring multidisciplinary treatment. Accurate preoperative assessment is critical for selecting the appropriate surgical technique, with transvaginal ultrasound (TVS) and endorectal …

BACKGROUND: Endometriosis is a common, chronic, estrogen-dependent gynecological disorder that significantly affects patients' quality of life. However, the disease burden and its trends may be undergoing significant changes, and comprehens…

The gut microbiota is a complex community of microorganisms that inhabit the human gastrointestinal tract, helping to maintain the ecological balance of the body's internal and external environments. Disruptions in the composition and diver…

BackgroundOvarian cancer is a highly lethal gynecological malignancy, with epithelial ovarian cancer (EOC) being its most common form. Surgery combined with chemotherapy is the standard treatment. Resection completeness significantly impact…

BackgroundThis retrospective study aimed to examine the influence of hormonal and metabolic parameters across varying body mass index (BMI) levels on embryo quality and pregnancy outcomes in fresh embryo transfer cycles using assisted repro…

Study questionCan third-generation sequencing (TGS)-based polar body (PB) analysis serve as a viable alternative to conventional trophectoderm (TE) biopsy for preimplantation genetic testing for aneuploidy (PGT-A)?Summary answerThis study d…

We present the case of a 39-year-old Chinese woman who presented with a palpable mass in her abdominal wall and pelvic cavity 9 years after undergoing laparoscopic myomectomy. Six abdominal wall fibroids, 18 intramural fibroids, 1 posterior…

Endometriosis is a chronic condition with limited therapeutic options. The molecular aberrations promoting ectopic attachment and interactions with the local microenvironment sustaining lesion growth have been unclear, prohibiting developme…