LV Adamyan

Benign uterine diseases remain among the leading causes of surgical interventions in women of reproductive age. A forty-year cumulative clinical experience (1986—2026) demonstrates that the effectiveness of reconstructive and uterus-preserv…

The endometrium during menstruation, as well as its fragments during intraperitoneal regurgitation, exhibit signs of aseptic inflammation. Therefore, the review summarizes current data on the possible mechanisms of survival and growth of en…

Genital endometriosis is a chronic multisystem disease in which pain syndrome remains the leading clinical manifestation. Despite significant advances in understanding the pathogenesis of endometriosis, the mechanisms of pain generation and…

I ntroduction. The innate immune system plays a leading role in the initiation and progression of external genital endometriosis (EGE) lesions. Aim. Тo analyze the content of subpopulations of immunocompetent cells and the level of cytokine…

Chronic pelvic pain is the most common symptom of endometriosis. Objective. To evaluate the effectiveness of amitriptyline for chronic pelvic pain associated with endometriosis. Material and methods. A comparative analysis of the results of…

Endometriosis is a gynecological disorder characterized by the presence of tissue that is morphologically and functionally similar to the endometrium, but located outside the uterine cavity. The disease is chronic and prone to recurrence. A…

This systematic review aimed to summarize all available data and evaluate the roles of E-cadherin, N-cadherin, associated molecules, and signaling pathways in the pathogenesis of endometriosis. The search was conducted on PubMed, Cochrane L…

Aim of the study. To study the morphological structure of scar tissue in patients with uterine scar defects (USD) after cesarean section (CS), as well as the effect of changes in mechanical stress in the area of the newly formed scar after …

• The limitations of EBM and guidelines to take dichotomous decisions, based on multiple variables, are discussed for endometriosis management. • It is suggested to document for clinical decisions on diagnosis, treatment and surgery the col…

The article focuses on the of methods for objectifying pain syndrome in patients with endometriosis. Endometriosis-related pain, including dysmenorrhea, dyspareunia, and chronic pelvic pain, is a clinically significant symptom of the diseas…

Background/Objectives: The diagnosis and treatment of endometriosis should be based on the best available evidence. Emphasising the risk of bias, the pyramid of evidence has the double-blind, randomised controlled trial and its meta-analyse…

The aim of this review is to analyse contemporary scientific evidence concerning the role and significance of macrophage polarisation in the pathogenesis of endometriosis. Particular emphasis is placed on the molecular and cellular mechanis…

Objective. Optimization of diagnostic methods for studying the myometrium in adenomyosis using magnetic resonance imaging (MRI) and subsequent construction of a three-dimensional model of the uterus using computer-assisted technologies to o…

Objective. Analysis of immunohistochemical expression of β1- and β2-adrenergic receptors (ADRB1 and ADRB2) in adenomyotic tissues in reproductive-age patients. Material and methods. The study included histological preparations and paraffin …

Abnormal uterine bleeding (AUB) is bleeding that is excessive in frequency, duration and/or volume of blood loss compared to normal menstruation. AUB is one of the most common gynecological problems and occurs in 3–30 % of women of reproduc…

• Endometriosis shows significant variation in its presentation and pathophysiology and is closely linked to fibrosis. • There is a critical need to provide insights in pathophysiology of endometriosis and to find new biomarkers and targets…

The mammary gland is a paired organ of the reproductive system, belonging to the type of apocrine glands of the skin. The main function of the mammary gland is the synthesis and secretion of milk. The structure and function of the mammary g…