Hironori Tashiro

AIM: Histopathologic diagnosis of a subset of uterine smooth muscle tumors is challenging. We report a critical review regarding the clinicopathological point of view of 62 cases of subsequently recurred or metastasized leiomyoma. METHODS:…

•A patient had endometrioid adenocarcinoma arising from endometriosis in the canal of Nuck.•The tumor invaded muscles in the inguinal region.•She showed favorable prognosis by radical surgery and adjuvant chemotherapy.

Ovarian clear cell adenocarcinoma (CCA) has been believed to be a lethal histological subtype of an epithelial ovarian adenocarcinoma (EOA); its precursor has been assumed to be endometriosis. However, it has been reported that CCAs occasio…

OBJECTIVE: As the number of younger women with endometrial carcinoma has increased, fertility-sparing treatments have received more attention. Although there have been several reports on conservative treatments with progestins for endometri…

腹水中には様々な種類の細胞が存在し，腹腔内環境を形成している。その中でもマクロファージは免疫機構の中心的役割を担い，微小環境の変化によってM1マクロファージとM2マクロファージに分化することが示されている。子宮内膜症患者では腹腔マクロファージが増加・活性化し，その発生や進展に関与すると考えられている。また，子宮内膜症が経卵管性に逆流する月経血に暴露される骨盤内に好発することから，月経血に含まれる子宮内膜組織がその発生に不可欠と考えられている。しかし，これまで腹腔マクロファージ…

There are several case reports of adenocarcinomas developing within adenomyosis. However, there is no report demonstrating the natural course from adenomyosis to adenocarcinoma. We report a patient (a 41-year-old Japanese woman) who was obs…

The human ovarian surface epithelium (hOSE) is a single layer of mesothelial-type primitive epithelial cells that are potential estrogen targets. It has been reported that hOSE cells can produce estrogen. However, the mechanisms that regula…

BACKGROUND The two most common types of uterine endometrial carcinoma, endometrioid (UEC) and serous (USC), differ in their histopathologic appearance and biologic behavior. Recent studies suggest that these differences may be associated wi…