Annette Staebler

Background: Deep endometriosis (DE) is a special form of endometriosis, one of the most common benign diseases in gynecology. In the specific case of DE, ectopic endometrium can be found not only in peritoneal but also in deeper tissue laye…

PurposeEndometrioid ovarian carcinoma (ENOC) is the second most-common type of ovarian carcinoma, comprising 10%-20% of cases. Recently, the study of ENOC has benefitted from comparisons to endometrial carcinomas including defining ENOC wit…

Abstract ARID1A (BAF250a) is a component of the SWI/SNF chromatin modifying complex, plays an important tumor suppressor role, and is considered prognostic in several malignancies. However, in ovarian carcinomas there are contradictory repo…

Abstract ARID1A (BAF250a) is a component of the SWI/SNF chromatin modifying complex, plays an important tumour suppressor role, and is considered prognostic in several malignancies. However, in ovarian carcinomas there are contradictory rep…

Endometriosis has yielded controversy on whether it constitutes a single disease or distinct types. Current classification systems poorly correlate with the severity of symptoms and do not provide prognostic tools that can guide management …

We aimed to validate the prognostic association of p16 expression in ovarian high-grade serous carcinomas (HGSC) and to explore it in other ovarian carcinoma histotypes. p16 protein expression was assessed by clinical-grade immunohistochemi…

The clinical presentation of endometriosis is highly heterogeneous. In a landmark study we have shown somatic cancer-driver mutations in deep infiltrating endometriosis, with at least one case having multiple sites harboring the same driver…

Expression of the pluripotency factors SOX-2, OCT-4, KLF-4, and NANOG was analyzed by quantitative real-time polymerase chain reaction, immunohistochemistry, and immunofluorescence microscopy in the endometrium, myometrium, and endometrioti…

Ovarian carcinomas consist of a heterogeneous group of malignant epithelial neoplasms with specific pathogenic mechanisms. This review provides a brief introduction to the different pathways of tumor progression and the associated molecular…

Adult stem cells are thought to be responsible for the high regenerative capacity of the human endometrium, and have been implicated in the pathology of endometriosis and endometrial carcinoma. The RNA-binding protein Musashi-1 is associate…

ObjectiveThis study was undertaken to evaluate the feasibility of autofluorescence laparoscopy in the diagnosis of endometriotic lesions.Study designProspective analysis of 83 consecutive patients undergoing laparoscopy for suspected endome…

Fragestellung: Aktive nicht pigmentierte Endometrioseherde werden häufig mit entzündlichen, postentzündlichen und unspezifischen Veränderungen des Peritoneums verwechselt bzw. gänzlich übersehen. Mit der Fluoreszenzdiagnostik steht in der G…

ObjectiveTo investigate cyclooxygenase (COX-2) expression within different endometriotic lesions and to assess whether these expression patterns correlate with clinical characteristics.DesignRetrospective cross-sectional study.SettingUniver…

Fragestellung: Vor dem Hintergrund einer sehr variablen histologischen Nachweisrate von 18 - 100 % wird die Diagnose Endometriose häufig ohne ein histologisches Korrelat gestellt. Ziel dieser Studie war die Beurteilung des Ausmaßes diagnost…

Fragestellung: Vor dem Hintergrund einer sehr variablen histologischen Nachweisrate von 18–100% wird die Diagnose Endometriose häufig ohne ein histologisches Korrelat gestellt. Ziel dieser Studie war die Beurteilung des Ausmaßes diagnostisc…