Vicky J. Young

No ORCID on file · 9 papers in corpus · active 2013-2017

Study types

  • article 6
  • review 2
  • dissertation 1

Condition tags

  • endometriosis 8
  • chronic_pelvic_pain 3
  • dysmenorrhea 2
  • infertility 2
  • dyspareunia 2
article 2017
Reduced Transforming Growth Factor-β Activity in the Endometrium of Women With Heavy Menstrual Bleeding
·doi:10.1210/jc.2016-3437

Context: Heavy menstrual bleeding (HMB) is common and incapacitating. Aberrant menstrual endometrial repair may result in HMB. The transforming growth factor (TGF)-β superfamily contributes to tissue repair, but its role in HMB is unknown. …

review 2017
The role of TGF-β in the pathophysiology of peritoneal endometriosis
Human reproduction update ·doi:10.1093/humupd/dmx016

BACKGROUND: Endometriosis is estimated to affect 6-10% of women of reproductive age and it is associated with chronic pelvic pain, dysmenorrhoea and subfertility. It is currently managed surgically or medically but symptoms recur in up to 7…

article 2016
ID2 mediates the transforming growth factor-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis
Molecular human reproduction ·doi:10.1093/molehr/gaw045

STUDY QUESTION: Is inhibitor of DNA-binding protein 2 (ID2) a mediator of the transforming growth factor (TGF)-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis? SUMMARY ANSWER: The TGF-β1-induced changes in …

article 2015
Peritoneal VEGF-A expression is regulated by TGF-β1 through an ID1 pathway in women with endometriosis
Scientific reports ·doi:10.1038/srep16859

VEGF-A, an angiogenic factor, is increased in the peritoneal fluid of women with endometriosis. The cytokine TGF-β1 is thought to play a role in the establishment of endometriosis lesions. Inhibitor of DNA binding (ID) proteins are transcri…

dissertation 2015
Role of the peritoneum and transforming growth factor β in the aetiology of endometriosis

Endometriosis is a benign inflammatory disorder, defined by the presence of endometrial \ntissue outside the uterus with lesions typically found on the pelvic peritoneum in close \nassociation with the peritoneal mesothelium. The prevalence…

article 2014
Metabolic reprogramming may underpin the aetiology of endometriosis
·doi:10.1530/repabs.1.p330

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)

article 2014
The Peritoneum Is Both a Source and Target of TGF-β in Women with Endometriosis
PloS one ·doi:10.1371/journal.pone.0106773

Transforming growth factor-β (TGF-β) is believed to play a major role in the aetiology of peritoneal endometriosis. We aimed to determine if the peritoneum is a source of TGF-β and if peritoneal TGF-β expression, reception or target genes a…

article 2014
Transforming Growth Factor-β Induced Warburg-Like Metabolic Reprogramming May Underpin the Development of Peritoneal Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2014-1026

CONTEXT: TGF-β is believed to play a major role in the etiology of peritoneal endometriosis. In tumors, TGF-β induces the metabolic conversion of glucose to lactate via glycolysis, a process referred to as the "Warburg effect." Lactate incr…

review 2013
The role of the peritoneum in the pathogenesis of endometriosis
Human reproduction update ·doi:10.1093/humupd/dmt024

BACKGROUND Endometriosis affects 6-10% of women of reproductive age and is associated with chronic pelvic pain, dysmenorrhoea, dyspareunia and infertility. Endometriosis is defined by the presence of endometrial tissue outside the uterus, m…