W. Colin Duncan

ORCID: 0000-0002-7170-5740 · 11 papers in corpus · active 1897-2017

Study types

  • article 8
  • review 2
  • book-chapter 1

Condition tags

  • endometriosis 7
  • mesh:D004715 5
  • dysmenorrhea 1
  • chronic_pelvic_pain 1
article 2017
·doi:10.1210/jc.2016-3437

Context: Heavy menstrual bleeding (HMB) is common and incapacitating. Aberrant menstrual endometrial repair may result in HMB. The transforming growth factor (TGF)-β superfamily contributes to tissue repair, but its role in HMB is unknown. …

review 2017
Human reproduction update ·doi:10.1093/humupd/dmx016

BACKGROUND: Endometriosis is estimated to affect 6-10% of women of reproductive age and it is associated with chronic pelvic pain, dysmenorrhoea and subfertility. It is currently managed surgically or medically but symptoms recur in up to 7…

article 2016
Molecular human reproduction ·doi:10.1093/molehr/gaw045

STUDY QUESTION: Is inhibitor of DNA-binding protein 2 (ID2) a mediator of the transforming growth factor (TGF)-β1-induced Warburg-like effect seen in the peritoneum of women with endometriosis? SUMMARY ANSWER: The TGF-β1-induced changes in …

book-chapter 2016
·doi:10.1007/978-3-319-43238-0_13
article 2015
Scientific reports ·doi:10.1038/srep16859

VEGF-A, an angiogenic factor, is increased in the peritoneal fluid of women with endometriosis. The cytokine TGF-β1 is thought to play a role in the establishment of endometriosis lesions. Inhibitor of DNA binding (ID) proteins are transcri…

article 2014
·doi:10.1530/repabs.1.p330

Searchable abstracts of presentations at key conferences on reproductive biology and medicine ISSN 2052-1472 (online)

article 2014
PloS one ·doi:10.1371/journal.pone.0106773

Transforming growth factor-β (TGF-β) is believed to play a major role in the aetiology of peritoneal endometriosis. We aimed to determine if the peritoneum is a source of TGF-β and if peritoneal TGF-β expression, reception or target genes a…

article 2014
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2014-1026

CONTEXT: TGF-β is believed to play a major role in the etiology of peritoneal endometriosis. In tumors, TGF-β induces the metabolic conversion of glucose to lactate via glycolysis, a process referred to as the "Warburg effect." Lactate incr…

review 2009
Reproduction, fertility, and development ·doi:10.1071/rd08272

The marked cyclical physiological angiogenesis in the developing follicle, corpus luteum and endometrium implies a critical role in health and disease. Our approach to understanding its regulation has been to localise and quantify the tempo…

article 1996
·doi:10.1677/joe.0.1480059

Tissue inhibitor of metalloproteinases-1 (TIMP-1) is a specific inhibitor of a group of proteolytic enzymes known as matrix metalloproteinases. These enzymes have been widely implicated in the process of tissue remodelling. Extensive remode…

article 1897
·doi:10.1016/s0140-6736(01)58840-6