Jacques Donnez

OBJECTIVE: To investigate the regulation of perimenstrual MMP-1 expression in human endometrium. DESIGN: In vitro study utilizing epithelial-stromal co-cultures. SETTING: Cell Biology Unit, International Institute of Cellular and Molecular …

The objective of this study was to analyse the histological and immunohistochemical characteristics of cultured explants of human endometrium transplanted into nude mice. Biopsies of eutopic endometrium were taken from six patients during l…

Various non-hysteroscopic procedures have been developed in the attempt to treat dysfunctional uterine bleeding that fails to respond to medical treatment efficiently and easily. Among these procedures is low-dose laser radiation of the end…

OBJECTIVE: To provide an overview of the medical, surgical and combined therapy options for endometriosis. RESULTS: Available medical options include danazol, progestogens, gestrinone, oral contraceptive agents, analgesics and gonadotropin-…

Objective: Laparoscopic procedure with excision of deep fibrotic\nendometriotic nodules of the rectovaginal septum and histological\nstudy of the lesions. \nSetting:\nAn academic teaching hospital.\nPatients: A series of 500 patients underw…

peer reviewed

ObjectiveTo determine whether interstitial collagenase (matrix metalloproteinase-1), known to play a pivotal role in the initiation of menstruation, contributes to the pathogenesis of endometriosis.DesignSerial sections of peritoneal red an…

ObjectiveTo assess the proliferative activity of eutopic and ectopic endometrium throughout the menstrual cycle and its correlation to steroid receptor content.DesignThe immunohistochemical use of Ki 67 was applied to investigate the prolif…

In the pelvis, three different forms of endometriosis must be considered: 1) peritoneal endometriosis; 2) ovarian endometriosis and 3) rectovaginal septum endometriosis.

Morphological and morphometric data showed similarities between eutopic endometrium and red peritoneal lesions, suggesting that these lesions are the first stage of early implantation of endometrial glands and stroma. An inflammatory reacti…

ObjectiveTo review the histogenesis of peritoneal, ovarian, and rectovaginal endometriotic lesions.DesignThe comparison of morphologic, morphometric, and histochemical data observed in each type of lesion.SettingA university hospital depart…

OBJECTIVE: Laparoscopic procedure with excision of deep fibrotic endometriotic nodules of the rectovaginal septum and histological study of the lesions. SETTING: An academic teaching hospital. PARTICIPANTS: A series of 500 women undergoing …

Recent studies suggest that interstitial collagenase (MMP-1) is an essential enzyme in the early events leading to menstruation. This study analyses its cellular origin, regulation and relation to extracellular matrix breakdown in the human…

The management of large endometriomas was described in a series of 814 patients. Combined therapy using gonadotrophin-releasing hormone agonist (GnRHa) and carbon dioxide laser laparoscopy was proposed. Drainage and GnRHa for 12 weeks provo…

This is a color-illustrated advanced clinical monograph that analyzes and compares the three forms of endometriosis: peritoneal, ovarian, and rectovaginal. Three core chapters cover the histopathology of peritoneal endometriosis, ovarian en…

Collagenases are the only mammalian enzymes able to cleave, at neutral pH, the triple helical domain of fibrillar collagens, major constituents of the extracellular matrix of the endometrium. Interstitial collagenase is expressed, secreted …

A computerized morphometrical investigation was performed on endometriotic tissue from the peritoneum (n = 225) and rectovaginal nodules (n = 65) to compare histologically and stereologically the rectovaginal septum endometriotic nodule to …

The human endometrium shows striking structural changes during the menstrual cycle. If no pregnancy develops, the fall of plasma progesterone and estradiol induces extracellular matrix degradation leading to haemorrhagia and mucosal sheddin…