Arne Vanhie

STUDY OBJECTIVE: To study whether bilateral nonpatency of fallopian tubes is correlated with a lower recurrence rate of endometriosis. DESIGN: Retrospective 2:1 matched case-control study. SETTING: University hospital with a tertiary refe…

Endometriosis-associated pain has debilitating effects on the quality of life of patients. Despite its high prevalence in reproductive-aged women, the pathophysiology is still unknown, impeding the development of targeted treatment approach…

Any ASRM stage [19] of en-dometriosis, any menstrual stage and any technique for miRNA expression analysis were allowed. Participant or population Patients with endometriosis.Intervention Assesment of circulating biomarkers.Comparator Asymp…

The aim of this systematic review is to assess the power of circulating miRNAs as biomarkers as a diagnostic tool in endometriosis. In endometriosis-suspected women with uncertain imaging, the only way to confirm or exclude endometriosis wi…

• Focal adenomyosis is a heterogeneous group of different entities. • Using sonographic features, five different types can be identified. • Correct identification of these forms may lead to new insights on symptoms and management of each of…

ABSTRACT Background Endometriosis is a complex disease, and its pathophysiology is still unclear. Therefore, endometriosis animal models need to be carefully selected and examined to be useful for identification of novel therapies for women…

RESEARCH QUESTION: What are the perspectives of preimplantation genetic testing (PGT) patients in Belgium on the ethics of PGT for polygenic risk scoring (PGT-P)? DESIGN: In-depth interviews (18 in total, 10 couples, 8 women, n = 28) were …

This is a monocentric retrospective study at a tertiary center for endometriosis. The primary objective of this study is to measure the prevalence of endometriosis in symptomatic but imaging negative patients undergoing diagnostic laparosco…

Endometriosis is a common condition associated with debilitating pelvic pain and infertility. A genome-wide association study meta-analysis, including 60,674 cases and 701,926 controls of European and East Asian descent, identified 42 genom…

Endometriosis is a chronic oestrogen-dependent gynaecological disease present in approximately 10% of women of reproductive age and up to 30–50% of women with infertility and/or pain. It is defined as the presence of endometrial-like tissue…

STUDY QUESTION: Can the Endometriosis Fertility Index (EFI) be estimated accurately before surgery? SUMMARY ANSWER: The EFI can be estimated accurately based on mere clinical/ultrasound information, with some improvement after adding data f…

Endometriosis is an important gynecological disease, affecting 10% of reproductive age women, and associated with pain, infertility, reduced quality of life, and high health economic cost. Except for ultrasound detection of ovarian endometr…

Successful pregnancy requires the establishment of a complex dialogue between the implanting embryo and the endometrium. Knowledge regarding molecular candidates involved in this early communication process is inadequate due to limited acce…

Endometrial disorders represent a major gynaecological burden. Current research models fail to recapitulate the nature and heterogeneity of these diseases, thereby hampering scientific and clinical progress. Here we developed long-term expa…

STUDY QUESTION: Can plasma miRNAs be used for the non-invasive diagnosis of endometriosis in infertile women? SUMMARY ANSWER: miRNA-based diagnostic models for endometriosis failed the test of independent validation. WHAT IS KNOWN ALREADY: …

sponsorship: The original work was supported by National Institutes of Health Grant HD076422 (to H.S.T.). (National Institutes of Health|HD076422)

There is a great need for a noninvasive diagnosis for endometriosis. Several biomarkers and biomarker panels have been proposed. Biomarker models consisting of CA-125, VEGF, Annexin V, and glycodelin/sICAM-1 were previously developed by our…

Endometriosis is a common gynecological disease that is characterized by the presence of functional endometrial-like lesions in the abdominal cavity. Aside from epithelial cells, these lesions consist of stromal cells that have the capacity…