Bilgin Gürateş

No ORCID on file · 26 papers in corpus · active 2000-2013

Study types

  • article 17
  • review 6
  • book-chapter 2
  • other 1

Condition tags

  • endometriosis 19
  • mesh:D004715 12
  • infertility 2
  • chronic_pelvic_pain 1
article 2013
Mullerian Inhibiting Substance Suppresses Proliferation and Induces Apoptosis and Autophagy in Endometriosis Cells In Vitro
ISRN obstetrics and gynecology ·doi:10.1155/2013/361489

Objective. To determine the effects of Mullerian inhibiting substance (MIS) treatment on endometriosis cells through study of apoptosis and autophagy. Design. Experimental in vitro study. Setting. University research laboratory. Cell Line. …

article 2012
Aromatase inhibitor treatment limits progression of peritoneal endometriosis in baboons
Fertility and sterility ·doi:10.1016/j.fertnstert.2012.11.021
other 2011
Medical Therapies: Aromatase Inhibitors
·doi:10.1002/9781444398519.ch35

Approximately half of women with endometriosis achieve pain relief from existing medical or surgical treatments. Medical treatments are usually directed at inhibiting estrogen action or its production from the ovaries and do not address loc…

article 2010
Association of WT1 and induction of apoptosis in endometriotic cell lines treated with MIS
·doi:10.1016/j.fertnstert.2010.07.778
book-chapter 2010
The Biology of Endometriosis
·doi:10.4324/9780203319390_chapter_9
article 2010
The Role of Mullerian Inhibiting Substance in Inducing Apoptosis in Ectopic Endometrium
·doi:10.1016/j.jmig.2010.08.480
article 2009
Prostaglandin E2 via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis
·doi:10.1210/mend.23.1.9997

ContextProducts of at least five specific steroidogenic genes, including steroidogenic acute regulatory protein (StAR), which facilitates the initial entry of cytosolic cholesterol into the mitochondrion, side-chain-cleavage enzyme (P450scc…

article 2008
Combating endometriosis by blocking proteasome and nuclear factor- B pathways
Human Reproduction ·doi:10.1093/humrep/den246

BACKGROUND: The objective of this study is to investigate the effect of pyrrolidine dithiocarbamate [PDTC; a nuclear factor-kappaB (NF-kappaB) inhibitor] and bortezomib (Velcade; a proteasome inhibitor) on the development of experimental en…

article 2008
Prostaglandin E2 Via Steroidogenic Factor-1 Coordinately Regulates Transcription of Steroidogenic Genes Necessary for Estrogen Synthesis in Endometriosis
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jc.2008-1180

CONTEXT: Products of at least five specific steroidogenic genes, including steroidogenic acute regulatory protein (StAR), which facilitates the entry of cytosolic cholesterol into the mitochondrion, side chain cleavage P450 enzyme, 3beta-hy…

review 2008
Steroidogenic factor-1 and endometriosis
Molecular and cellular endocrinology ·doi:10.1016/j.mce.2008.12.012
review 2005
Aromatase in endometriosis and uterine leiomyomata
The Journal of steroid biochemistry and molecular biology ·doi:10.1016/j.jsbmb.2005.04.012
article 2004
Intact progesterone receptors are essential to counteract the proliferative effect of estradiol in a genetically engineered mouse model of endometriosis
Fertility and Sterility ·doi:10.1016/j.fertnstert.2004.01.048
review 2003
Endometriosis: The Ultimate Hormonal Disease
Seminars in reproductive medicine ·doi:10.1055/s-2003-41319

Estrogen is an extremely potent mitogen for endometrium and endometriosis. Progesterone, on the other hand, inhibits the mitogenic action of estrogen on endometrium and enhances differentiation. These antiproliferative and differentiative e…

article 2003
Hormonal Açidan Endometriyozis
book-chapter 2003
Treatment with Aromatase Inhibitors
·doi:10.1201/b14235-12
review 2002
A Modified Baboon Model for Endometriosis
Annals of the New York Academy of Sciences ·doi:10.1111/j.1749-6632.2002.tb02791.x

Endometriosis is one of the most common causes of infertility and chronic pelvic pain and affects 1 in 10 women in the reproductive-age group. Although existence of this disease has been known for over 100 years, our current knowledge of it…

review 2002
Estrogen Production and Metabolism in Endometriosis
Annals of the New York Academy of Sciences ·doi:10.1111/j.1749-6632.2002.tb02767.x

Aromatase activity is absent in normal endometrium. In contrast, aromatase is expressed aberrantly in endometriosis, which gives rise to strikingly high levels of aromatase activity in this tissue. Both aromatase expression and activity are…

article 2002
Genetic or Enzymatic Disruption of Aromatase Inhibits the Growth of Ectopic Uterine Tissue
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.7.8683

Aromatase P450 (P450arom) is the key enzyme for the biosynthesis of estrogen that is essential for the growth of human endometriosis, a pathology characterized by endometrium-like tissue on the peritoneal surfaces of abdominal organs manife…

article 2002
Intact progesterone receptors are essential to counteract the proliferative effect of estrogen in a transgenic mouse model of endometriosis
·doi:10.1016/s0015-0282(02)03606-3
review 2002
Mechanisms of excessive estrogen formation in endometriosis
Journal of reproductive immunology ·doi:10.1016/s0165-0378(01)00132-2
article 2002
Regulation of Aromatase P450 Expression in Endometriotic and Endometrial Stromal Cells by CCAAT/Enhancer Binding Proteins (C/EBPs): Decreased C/EBPβ in Endometriosis Is Associated with Overexpression of Aromatase
The Journal of clinical endocrinology and metabolism ·doi:10.1210/jcem.87.5.8486

In human endometriotic stromal cells, markedly high levels of aromatase P450 (P450arom) mRNA and promoter II activity are present and can be vigorously stimulated by PGE(2) via a cAMP-dependent pathway to give rise to physiologically signif…

article 2002
Wilms’ tumor 1 inhibits aromatase P450 expression in human cells and is downregulated in endometriosis vs. endometrium-derived stromal cells
·doi:10.1016/s0015-0282(02)03385-x
article 2001
Regulation of aromatase P450 promoter (II) activity in endometriotic stromal cells by CCAAT/enhancer binding proteins (C/EBPs).
·doi:10.1016/s0015-0282(01)02149-5
article 2001
Transcriptional regulation of the CYP1A1 gene by dioxin in eutopic endometrial and endometriotic stromal cells.
·doi:10.1016/s0015-0282(01)02156-2
article 2001
Treatment with the aromatase inhibitor letrozole significantly reduced the size of ectopic uterine implants.
·doi:10.1016/s0015-0282(01)02153-7