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Abstract Purpose To quantify how anatomical compartment involvement—derived from standardised intraoperative mapping at 29 pelvic sites—predicts the need for segmental rectal resection in deep infiltrating endometriosis (DIE). We also c…

BACKGROUND: With the increasing use of assisted reproductive technology (ART), more women with endometriosis are achieving pregnancy through ART. However, the impact of endometriosis on pregnancy and perinatal outcomes following ART remains…

Introduction and aimsOral squamous cell carcinoma (OSCC) is a common malignant tumour of the head and neck region. In recent years, the relationship between pyroptosis and tumours has received increasing attention. However, its regulatory m…

BackgroundSexually transmitted infections (STIs) contribute to female infertility by causing pelvic inflammatory disease (PID) and fallopian tube damage. Utilizing the Global Burden of Disease (GBD) database, we aim to comprehensively evalu…

Human endometrial receptivity is a critical determinant of pregnancy success; however, in vivo studies of its features and regulation are particularly challenging due to ethical restrictions. Recently, the development of human endometrial a…

BACKGROUND: Inflammation has been linked to female fertility, yet its impact on ovarian reserve and response remains unclear. This study investigates the associations between systemic inflammatory markers, ovarian reserve—assessed by anti-M…

Endometriosis, a prevalent gynecological disease affecting women's health, involves altered immune function. This study investigates the immune checkpoint protein, V-domain immunoglobulin suppressor of T cell activation (VISTA) as a therape…

Endometrial polyps (EPs) are common uterine lesions associated with abnormal uterine bleeding and infertility, yet their pathogenesis remains poorly defined. Here, we performed single-cell RNA sequencing of normal endometrium, para-polyp, a…

Jing Li,1 Yang Yang,2 Teng Li,1 Bowei Sun,3 Yongai Zhang1 1Department of Nursing and Rehabilitation College, Xi’an Medical University, Xi’an, Shaanxi, 710021, People’s Republic of China; 2Department of Reproductive Medicine, Xi’an People’s …

ObjectiveTo explore the correlation between autoantibodies, ultrasonic endometrial receptivity parameters and early miscarriage in recurrent spontaneous abortion (RSA) patients during subsequent pregnancies, and to establish and validate a …

BACKGROUND: The long noncoding RNA (lncRNA) FAM83H-AS1 plays a critical role in the development and progression of various cancers. This study evaluates the feasibility of serum FAM83H-AS1 as a diagnostic and staging marker for ovarian canc…

Polycystic ovary syndrome (PCOS) and Endometriosis (EMs) are common reproductive endocrine disorders in women of reproductive age, characterized by the co-occurrence of infertility, chronic low-grade inflammation, and chronic pelvic pain. I…

Primary peritoneal serous borderline tumor (PPSBT) is a rare, low-malignant-potential neoplasm arising from the peritoneum, diagnosed only after excluding ovarian involvement. While typically discovered incidentally during surgery, it often…

Immune escape is a phenomenon in which tumor cells or infections evade detection and clearance by the host immune system in various ways. During an antitumor immune response, cells increase the concentration of pentameric stalk, which enhan…

BackgroundThe cardiometabolic index (CMI) is a new comprehensive measure that reflects visceral obesity and metabolic function. This study aimed to examine associations between CMI and adult mortality from all causes and specific causes, as…

Hu sheep are renowned for their adaptation to high-temperature, humid environments and their high fecundity. Despite serving as the founder species for sheep breeding in China, the genetic mechanisms underlying these desirable traits and th…

Cervical and ovarian cancers pose a significant global threat to women's health. Despite substantial medical advances in recent decades, gynecological malignancies remain a leading cause of female mortality, constrained by factors such as m…

ObjectiveTo identify potential druggable targets for Alzheimer's disease (AD) by analyzing circulating inflammatory proteins using Mendelian randomization (MR).MethodsTwo-sample MR analysis was employed to investigate the causal relationshi…

Ageing of the endometrium is a critical factor that affects reproductive health, yet its intricate mechanisms remain poorly explored. In this study, we performed transcriptome profiling and experimental verification of endometrium and endom…

BackgroundWith the increasing use of assisted reproductive technology (ART) as a solution for infertility, understanding patient knowledge, attitudes, and practices (KAP) is essential. This study aimed to assess the KAP of infertile women i…

BACKGROUND: Endometriosis (EMS) is characterized by the occurrence, growth, infiltration, and recurrent bleeding of endometrial tissue outside the uterus. Recent studies have revealed a close association between Neutrophil Extracellular Tra…

Zailong Xu,1,* Rui Ji,2,* Mei Wang,1 Tiantian Li,1 Hui Hu1 1Department of Obstetrics and Gynecology, Pudong New Area People’s Hospital in Shanghai, Shanghai, People’s Republic of China; 2Department of Obstetrics and Gynecology, Shan…

Progressive dysmenorrhea and extensive fibrosis within the myometrium are hallmark features of adenomyosis (AM). Approximately 80% of patients with AM experience secondary dysmenorrhea, which occurs more frequently in AM than in other gynec…

Colorectal cancer (CRC) is a common malignancy, and TRIM24, an E3 ubiquitin ligase, is a potential target for various cancers. This study found high TRIM24 expression in CRC, correlating with poor prognosis and disease progression. Oroxin A…