L Chen

STUDY QUESTION: Can a panel of plasma protein biomarkers be identified to accurately and specifically diagnose endometriosis? SUMMARY ANSWER: A novel panel of 10 plasma protein biomarkers was identified and validated, demonstrating strong …

OBJECTIVE: This retrospective study explored the potential connection between adenomyosis and pregnancy outcomes. PATIENTS AND METHODS: A study included data from a total of 1,208 pregnancies. The adenomyosis group included 334 pregnant wo…

Although endometriosis could be associated with certain epithelial ovarian cancers and elevated serum cancer antigen (CA) 19-9 levels, it is difficult to diagnose endometriosis using this marker. We report an unusual case of endometriosis t…

Objective: To investigate the role of adenosine diphosphate ribosylation factor 6 (Arf6) in the pathogenesis of endometriosis. Methods: Endometrial tissues were sampled from women who were hospitalized in the Affiliated Hospital of Medical …

AIM: To investigate the value of amide proton transfer weighted (APTw) imaging and R2∗ mapping of cystic fluid in differentiating ovarian endometriotic cysts (OE) from other ovarian cystic (OOC) lesions. MATERIALS AND METHODS: A total of 4…

Endometriosis is a common gynecological pathology with the abdominal wall endometriosis (AWE) being a rarer one but with increasing frequency probably to the increased rate of deliveries by cesarean sections. Endometrial tissue is hormone r…

Background. Endometriosis (EMs) is a non-malignant gynecological disease, whose pathogenesis remains to be clarified. Recent studies have found that hypoxia induces epithelial-mesenchymal transition (EMT) as well as epigenetic modification …

OBJECTIVE: The aim of this study was to compare the therapeutic outcomes of high-intensity focused ultrasound (HIFU) and surgical treatment for abdominal wall endometriosis. DESIGN: A retrospective study. SETTING: Gynaecological departmen…

O1 The metabolomics approach to autism: identification of biomarkers for early detection of autism spectrum disorder A. K. Srivastava, Y. Wang, R. Huang, C. Skinner, T. Thompson, L. Pollard, T. Wood, F. Luo, R. Stevenson O2 Phenome-wide ass…

OBJECTIVE: Frailty is the loss of physical or mental reserve that impairs function, often in the absence of a defined comorbidity. Our aim was to determine whether a modified frailty index (mFI) correlates with morbidity and mortality in pa…

OBJECTIVE: To investigate the incidence, influencing factors and intervention of gestrinone-related abnormal uterine bleeding at different dosage of gestrinone in the clinical treatment. METHODS: This was a multicenter, randomized, control…

Adenomyosis is a common benign disease that usually affects women of reproductive age, which is characterized by the growth of endometrial glands and stroma into the myometrium. Hysterectomy by laparotomy or laparoscopy is currently leading…

Aim: To investigate the expressions and functions of uPA and PAI-1 in the etiology and pathogenesis of endometriosis. Methods: Immunohistochemistry method was used to detect the expressions of uPA and PAI-1 in 40 cases of ectopic endometriu…

【Objective】To investigate the function of uPAR in genesis and development of endometriosis.【Methods】Immunohistochemistry method was applied to detect the expression of uPAR protein in 40 cases of ectopic endometrium, 40 cases of eutopic end…

OBJECTIVE: To research the relationship between polymorphism of trinucleotide (CAG)n repeat alleles of the Exon 1 of androgen receptor gene and women with polycystic ovary syndrome (PCOS), or with endometriosis. MATERIALS AND METHODS: One …