Role of uPAR in development and clinical stages of endometriosis

【Objective】To investigate the function of uPAR in genesis and development of endometriosis.【Methods】Immunohistochemistry method was applied to detect the expression of uPAR protein in 40 cases of ectopic endometrium, 40 cases of eutopic endometrium and 30 cases of endometrium without endometriosis.【Resluts】UPAR protein was expressed in stromal and epithelial cells from ecpotic,eutopic and normal endometrium, and also detected positively in vascular endothelial cells. uPAR protein was significantly higher from epithelial cells than from stromal cells in ecpotic,eutopic and normal endometrium(P0.05). uPAR protein in epithelial cells was increased in ectopic endometrium compared with eutopic and normal endometrium(P0.05).There was no statistical significance between the level of uPAR in stage Ⅰ~Ⅱ and stage Ⅲ ~ Ⅳ of ectopic endometrium(P0.05).【Conclusion】The overexpression of uPAR protein in endometriotic stromal cells might be of importance for the migratory,adherance,invasion and growth,which maybe result in endomrtriosis in the end.Study on the effect of uPAR has a certain guiding significance for clinical treatment of endometriosis.