Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol

Eva Skovlund, Gunnar Fyllingen, H. Landre, B I Nesheim
In: European Journal of Clinical Pharmacology · 1991 · vol. 40(6) , pp. 539–542 · doi:10.1007/bf00279965 · PMID:1884732 · W121866855
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-13 ⓘ

A sequential trial comparing naproxen and paracetamol for postpartum uterine cramps found no significant difference in efficacy between the two treatments in 56 patients.

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The study compared naproxen versus paracetamol for relief of uterine cramps in a sequential trial involving 56 patients, using two-sided testing to evaluate whether the treatments differed. The authors found no statistically significant difference between naproxen and paracetamol, and they noted that a comparable fixed-sample test would have required 140 patients to reach the same significance level and power. The trial also estimated effects on episiotomy pain at termination, again indicating no clear difference between the two treatments. The paper does not explicitly discuss endometriosis or adenomyosis; it was included in the corpus via a keyword match in the upstream search index.

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Abstract

The efficacy of naproxen and paracetamol in relieving uterine cramps has been compared in a sequential trial. The treatments did not differ significantly in a two-sided test in 56 patients. A corresponding fixed sample test would have required 140 patients to obtain the same significance level and power. In addition to uterine pain, the effect on episiotomy pain was also estimated at the termination of the trial. Again, there seemed to be no difference between naproxen and paracetamol.
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Summary The efficacy of naproxen and paracetamol in relieving uterine cramps has been compared in a sequential trial. The treatments did not differ significantly in a two-sided test in 56 patients. A corresponding fixed sample test would have required 140 patients to obtain the same significance level and power. In addition to uterine pain, the effect on episiotomy pain was also estimated at the termination of the trial. Again, there seemed to be no difference between naproxen and paracetamol. Access this article We’re sorry, something doesn't seem to be working properly. Please try refreshing the page. If that doesn't work, please contact support so we can address the problem. Similar content being viewed by others References Bloomfield SS, Barden TP, Mitchell J (1977) Naproxen, aspirin, and codeine in postpartum uterine pain. Clin Pharmacol Ther 21: 414–421 Bloomfield SS, Cissell GB, Peters NM, Mitchell J, Nelson ED, Barden TP (1987) Anirolac vs. naproxen for postpartum uterine pain. Clin Pharmacol Ther 42: 89–95 Csapo AI, Pulkkinen MO, Henzl MR (1977) The effect of naproxen-sodium on the intrauterine pressure and menstrual pain of dysmenorrhoeic patients. Prostaglandins 13: 193–199 Henzl MR, Buttram V, Segre EJ, Bessler S (1977) The treatment of dysmenorrhoea with naproxen sodium. A report on two independent double-blind trials. Am J Obstet Gynecol 127: 818–823 Lawrence RA (1989) Breastfeeding - A guide for the medical profession. 3rd ed. Mosby, St. Louis Lehmann EL (1975) Nonparametrics: Statistical methods based on ranks. Holden-Day, San Francisco Lundström V, Green K, Wiqvist N (1976) Prostaglandins, indomethacin and dysmenorrhoea. Prostaglandins 11: 893–904 Milsom I, Andersch B (1984) Ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhea. Br J Obstet Gynaecol 91: 1129–1135 Pulkkinen MO, Csapo AI (1978) The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrhoeic patients. Prostaglandins 15: 1055–1062 Skovlund E, Walløe L (1988) A sequential two-sample test developed by stochastic simulation. J Stat Comput Simul 29: 87–104 Skovlund E, Walløe L (1989) Estimation of treatment difference following a sequential clinical trial. JASA 84: 823–828 Skovlund E (1991) Truncation of a two sample sequential Wilcoxon test. Biometr J, 3 (in press) Skovlund E, Fyllingen G, Landre H, Nesheim B-I (1991) Comparison of postpartum pain treatments using a sequential trial design. I. Paracetamol versus placebo. Eur J Clin Pharmacol, 40, (in press) Author information Authors and Affiliations Rights and permissions About this article Cite this article Skovlund, E., Fyllingen, G., Landre, H. et al. Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol. Eur J Clin Pharmacol 40, 539–542 (1991). https://doi.org/10.1007/BF00279965 Received: Accepted: Issue date: DOI: https://doi.org/10.1007/BF00279965

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