{"paper_id":"ff8fc818-012b-4de1-b571-8ad333d91bb8","body_text":"Summary\nThe efficacy of naproxen and paracetamol in relieving uterine cramps has been compared in a sequential trial. The treatments did not differ significantly in a two-sided test in 56 patients. A corresponding fixed sample test would have required 140 patients to obtain the same significance level and power.\nIn addition to uterine pain, the effect on episiotomy pain was also estimated at the termination of the trial. Again, there seemed to be no difference between naproxen and paracetamol.\nAccess this article\nWe’re sorry, something doesn't seem to be working properly.\nPlease try refreshing the page. If that doesn't work, please contact support so we can address the problem.\nSimilar content being viewed by others\nReferences\nBloomfield SS, Barden TP, Mitchell J (1977) Naproxen, aspirin, and codeine in postpartum uterine pain. Clin Pharmacol Ther 21: 414–421\nBloomfield SS, Cissell GB, Peters NM, Mitchell J, Nelson ED, Barden TP (1987) Anirolac vs. naproxen for postpartum uterine pain. Clin Pharmacol Ther 42: 89–95\nCsapo AI, Pulkkinen MO, Henzl MR (1977) The effect of naproxen-sodium on the intrauterine pressure and menstrual pain of dysmenorrhoeic patients. Prostaglandins 13: 193–199\nHenzl MR, Buttram V, Segre EJ, Bessler S (1977) The treatment of dysmenorrhoea with naproxen sodium. A report on two independent double-blind trials. Am J Obstet Gynecol 127: 818–823\nLawrence RA (1989) Breastfeeding - A guide for the medical profession. 3rd ed. Mosby, St. Louis\nLehmann EL (1975) Nonparametrics: Statistical methods based on ranks. Holden-Day, San Francisco\nLundström V, Green K, Wiqvist N (1976) Prostaglandins, indomethacin and dysmenorrhoea. Prostaglandins 11: 893–904\nMilsom I, Andersch B (1984) Ibuprofen, naproxen sodium and paracetamol on intrauterine pressure and menstrual pain in dysmenorrhea. Br J Obstet Gynaecol 91: 1129–1135\nPulkkinen MO, Csapo AI (1978) The effect of ibuprofen on the intrauterine pressure and menstrual pain of dysmenorrhoeic patients. Prostaglandins 15: 1055–1062\nSkovlund E, Walløe L (1988) A sequential two-sample test developed by stochastic simulation. J Stat Comput Simul 29: 87–104\nSkovlund E, Walløe L (1989) Estimation of treatment difference following a sequential clinical trial. JASA 84: 823–828\nSkovlund E (1991) Truncation of a two sample sequential Wilcoxon test. Biometr J, 3 (in press)\nSkovlund E, Fyllingen G, Landre H, Nesheim B-I (1991) Comparison of postpartum pain treatments using a sequential trial design. I. Paracetamol versus placebo. Eur J Clin Pharmacol, 40, (in press)\nAuthor information\nAuthors and Affiliations\nRights and permissions\nAbout this article\nCite this article\nSkovlund, E., Fyllingen, G., Landre, H. et al. Comparison of postpartum pain treatments using a sequential trial design: II. Naproxen versus paracetamol. Eur J Clin Pharmacol 40, 539–542 (1991). https://doi.org/10.1007/BF00279965\nReceived:\nAccepted:\nIssue date:\nDOI: https://doi.org/10.1007/BF00279965","source_license":"CC0","license_restricted":false}