Malignant Peritoneal Mesothelioma Associated With Endometriosis: A Clinicopathologic Study of 15 Cases

Malpica A, Anais Malpica, Elizabeth D. Euscher, Euscher ED, Mario L Marques-Piubelli, Mario L. Marques‐Piubelli, Marques-Piubelli ML, Roberto N. Miranda, Miranda RN, Keith F. Fournier, Fournier KF, Kanwal P. Raghav, Raghav KP, Preetha Ramalingam, Ramalingam P
International journal of gynecological pathology : official journal of the International Society of Gynecological Pathologists · 2021 · vol. 41(1) , pp. 59–67 · doi:10.1097/pgp.0000000000000762 · PMID:33577225 · W3128404370
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This clinicopathologic study of 15 malignant peritoneal mesothelioma cases found an association with personal/familial malignancy history, suggesting this may be a predisposing factor, while endometriosis' role is less clear.

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Abstract

Only a few cases of malignant peritoneal mesothelioma (MPeM) associated with endometriosis have been published; with chronic inflammation of the peritoneum associated with the latter being postulated as an inducing factor in the pathogenesis of this tumor. We assessed the clinicopathologic characteristics of MPeM associated with endometriosis to determine if there were other factors besides inflammation that may contribute to the pathogenesis in this patient population. Fifteen MPeM associated with endometriosis were retrieved from our files. Most presented with abdominal/pelvic pain, mass or distention; median age was 45 yr. Only 16% of patients had a history of asbestos exposure. In contrast, a third of the patients had a personal history of other neoplasms, and >80% had a family history of malignancies. Although most tumors had gross and microscopic features typical of MPeM, some had confounding features including "adhesion-like" appearance or gelatinous cysts/nodules, and signet ring cells. Tumors were epithelioid (9) and biphasic (6). MPeM was misdiagnosed as Müllerian carcinoma in 40% of cases. All patients (n=15) had cytoreductive surgery in addition to other therapies. Only 2/12 patients died of disease (17%). The 3- and 5-yr overall survival was 90%. MPeM associated with endometriosis tends to occur in patients with personal/familial history of malignancies, which may be a predisposing factor. In light of this finding, the role of endometriosis in the pathogenesis of MPeM is likely less relevant. The favorable outcome seen in these patients may be related to germline mutations or the hormonal milieu and needs further investigation.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Mesothelioma, Malignant Peritoneal Neoplasms Adolescent Adolescent Adult Adult Aged Aged Cohort Studies Cohort Studies Cytoreduction Surgical Procedures Cytoreduction Surgical Procedures Endometriosis Endometriosis Endometriosis Endometriosis Female Female Germ-Line Mutation

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (34)

Source provenance

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