Evaluation of YB-1 levels in patients with endometriosis

Ahrens T, Thorben Ahrens, Silveira CG, Cássia Gisele Terrassani Silveira, Cassia G T Silveira, Constanze Banz‐Jansen, Banz-Jansen C, Constanze Banz-Jansen, Rody A, Achim Rody, Hornung D, Daniela Hornung
European journal of obstetrics, gynecology, and reproductive biology · 2015 · vol. 191 , pp. 68–71 · doi:10.1016/j.ejogrb.2015.05.008 · PMID:26093350 · W1954251083
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This study investigated YB-1 levels in patients diagnosed with endometriosis to understand its potential role in the condition.

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Abstract

OBJECTIVE: The objective of this study is the evaluation of serum YB-1 levels in the diagnosis of endometriosis. STUDY DESIGN: Serum samples of 12 patients with histologically confirmed endometriosis and of 10 control patients were collected. Western blot analysis was used to assess serum YB-1 levels. Groups were compared with Student's t-test or, if not normally distributed, with the Mann-Whitney test. Sensitivity and specificity for the potential diagnostic performance of serum YB-1 were assessed by receiver operating characteristic (ROC) curves. RESULTS: Serum YB-1 levels were significantly higher in patients with endometriosis (=0.004). The area under the curve was 0.867 (95% confidence interval 0.714-1.019) with sensitivity and specificity of 83.3% and 70% respectively. CONCLUSIONS: Serum YB-1 levels in patients with endometriosis are significantly higher compared to control patients and may be used as a potential diagnostic biomarker for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Up-Regulation Up-Regulation Y-Box-Binding Protein 1 Adult Adult Biomarkers Biomarkers Biomarkers Blotting, Western Blotting, Western Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (47)

Cited by (1)

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