Evaluation of YB-1 levels in patients with endometriosis

Ahrens T, Thorben Ahrens, Silveira CG, Cássia Gisele Terrassani Silveira, Cassia G T Silveira, Constanze Banz‐Jansen, Banz-Jansen C, Constanze Banz-Jansen, Rody A, Achim Rody, Hornung D, Daniela Hornung
European journal of obstetrics, gynecology, and reproductive biology · 2015 · vol. 191 , pp. 68–71 · doi:10.1016/j.ejogrb.2015.05.008 · PMID:26093350 · W1954251083
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⚙ AI-generated summary by claude@2026-06, 2026-06-10 ⓘ

This study investigated YB-1 levels in patients diagnosed with endometriosis to understand its potential role in the condition.

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Abstract

ObjectiveThe objective of this study is the evaluation of serum YB-1 levels in the diagnosis of endometriosis.Study designSerum samples of 12 patients with histologically confirmed endometriosis and of 10 control patients were collected. Western blot analysis was used to assess serum YB-1 levels. Groups were compared with Student's t-test or, if not normally distributed, with the Mann-Whitney test. Sensitivity and specificity for the potential diagnostic performance of serum YB-1 were assessed by receiver operating characteristic (ROC) curves.ResultsSerum YB-1 levels were significantly higher in patients with endometriosis (=0.004). The area under the curve was 0.867 (95% confidence interval 0.714-1.019) with sensitivity and specificity of 83.3% and 70% respectively.ConclusionsSerum YB-1 levels in patients with endometriosis are significantly higher compared to control patients and may be used as a potential diagnostic biomarker for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Ovarian Diseases Up-Regulation Y-Box-Binding Protein 1 Adult Biomarkers Biomarkers Blotting, Western Endometriosis Endometriosis Endometriosis Female Humans Ovarian Diseases Ovarian Diseases Ovarian Diseases ROC Curve Sensitivity and Specificity Y-Box-Binding Protein 1

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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