The role of intercellular adhesion molecule sICAM-1 in blood serum and peritoneal fluid in external genital endometriosis

This study evaluated whether soluble intercellular adhesion molecule sICAM-1 levels correlate with the severity and activity of external genital endometriosis, measuring sICAM-1 in blood serum and peritoneal fluid by ELISA in 25 surgically treated, histologically confirmed patients. Using nonparametric statistics and Spearman correlations, the authors found the highest mean serum sICAM-1 levels in groups with severe and moderate pain syndrome, and reported a significant increase in stages 3–4 in the severe pain group (1295.00 ± 709.4 ng/ml) versus an asymptomatic group (240.3 ± 82 ng/ml; p < 0.001). The paper’s limitation is its small sample size and single-center design, which constrains the generalizability of the findings. This paper is centrally about endometriosis — it focuses on sICAM-1 in blood serum and peritoneal fluid as a marker of the activity and progression of external genital endometriosis.

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