Cost–effectiveness of elagolix versus leuprolide acetate for treating moderate-to-severe endometriosis pain in the USA

Wang ST, Si‐Tien Wang, Si-Tien Wang, Scott J. Johnson, Johnson SJ, Dominic Mitchell, Ahmed M. Soliman, Jamie Vora, Vora JB, Jamie B Vora, Sanjay K. Agarwal
Journal of comparative effectiveness research · 2019 · vol. 8(5) , pp. 337–355 · doi:10.2217/cer-2018-0124 · PMID:30724096 · W2912011793
article OA: hybrid CC0 ⤵ 9 in-corpus citations
🔓 Open OA copy View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

Elagolix was cost-effective compared to leuprolide acetate for treating moderate-to-severe endometriosis pain in the US over 1- and 2-year time horizons, showing positive net monetary benefits.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

AIM: To assess the cost-effectiveness of elagolix versus leuprolide acetate in women with moderate to severe endometriosis pain. METHODS: A Markov model was developed. The efficacy of leuprolide acetate was derived from statistical prediction models using elagolix trial data. Model inputs were extracted from Phase III clinical trials and published literature. RESULTS: Compared with leuprolide acetate, elagolix generated positive net monetary benefit (NMB) assuming a payer's willingness-to-pay threshold of US$100,000 per quality-adjusted life year over a 1-year time horizon: US$5660 for elagolix 150 mg and US$6443 for elagolix 200 mg. The 2-year NMBs were also positive. CONCLUSION: Elagolix was cost effective versus leuprolide acetate in the management of moderate to severe endometriosis pain over 1- and 2-year time horizons. Results were robust in sensitivity analyses.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Endometriosis Fertility Agents, Female Hydrocarbons, Fluorinated Leuprolide Pyrimidines Adolescent Adult Cost-Benefit Analysis Endometriosis Endometriosis Female Fertility Agents, Female Fertility Agents, Female Humans Hydrocarbons, Fluorinated Hydrocarbons, Fluorinated Leuprolide Leuprolide Markov Chains Middle Aged

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (53)

Cited by (9)

Source provenance

europepmc
last seen: 2026-09-27T09:11:36.575535+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:23:01.605684+00:00
License: CC0 · commercial use OK