Association of TNF-α gene T-1031C polymorphism with endometriosis: A meta-analysis

Cao XL, Xian-Ling Cao, Xianling Cao, J.F. Chai, Chai J, Jie Chai, Yu YY, Yang-Yang Yu, Yangyang Yu, Tian X, Xiao Tian, Jian-Yun Zhao, Jian‐Yun Zhao, Zhao JY, Yu LY, Ling‐Yu Yu, Ling-Yu Yu, Zhen‐Gao Sun
American journal of reproductive immunology (New York, N.Y. : 1989) · 2020 · vol. 84(6) , pp. e13305 · doi:10.1111/aji.13305 · PMID:32683731 · W3043704647
Systematic review / meta-analysis OA: closed CC0 ⤵ 6 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-09 ⓘ

This meta-analysis of seven studies found that the TNF-α T-1031C polymorphism is associated with endometriosis susceptibility, showing a protective effect in Asian and European populations.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The single nucleotide polymorphism T-1031C has shown to have an important role in the regulation and transcription efficiency of TNF-α gene. Yet, the relationship between TNF-α T-1031C gene polymorphism and the development of endometriosis (EM) still remains unclear. The aim of this meta-analysis was to summarize the effects of TNF-α T-1031C gene polymorphism and clarify their possible association with EM. A comprehensive literature search was performed using PubMed, EMBASE, Web of Science, and the Cochrane Central Register of Controlled Trials (up to August 10, 2019). A fixed- or random-effects model was employed according to the heterogeneity among studies. The log odds ratios and 95% confidence intervals (CIs) were estimated in the models of allele comparison (T vs C), homozygote comparison (TT vs CC) and (TC vs CC), dominant (TT vs TC + CC), hyperdominant (TT + CC vs TC), and recessive (TT + TC vs CC) to estimate the strength of the associations. A total of 7 case-control studies were included in this meta-analysis. Overall, significant associations between TNF-α T-1031C and EM were identified from (T vs C: log OR [95% CI] = 0.31 [-0.09, 0.71]; TT + CC vs TC: 0.27 [0.04, 0.50]; TC + CC vs TT: -0.83 [-1.19, -0.47]). On the other hand, no significant correlation was found in other gene models (TT vs TC: log OR [95% CI] = 0.89 [0.64, 1.13]; TT vs CC: 0.3 [-0.74, 1.36]; TT + TC vs CC: 0.17 [-0.81, 1.15]). In subgroup analyses by ethnicity or HWE P-value, there was a statistically significant association between TNF-α T-1031C polymorphisms and EM in the dominant model (TT vs TC + CC: log OR [95%] = -0.84 [-1.60, -0.09]) for the European population, and in hyperdominant model (TT + CC vs TC: log OR [95%] = 0.24 [0.001, 0.49]) for Asian population. To sum up, this meta-analysis showed that TNF-α T-1031C polymorphism was associated with EM susceptibility and has a protective effect in Asian and European populations.

My notes (saved in your browser only)

Condition tags

endometriosis

MeSH descriptors

Asian People Asian People Endometriosis Genotype Genotype Tumor Necrosis Factor-alpha White People White People Endometriosis Endometriosis Female Female Gene Frequency Gene Frequency Genetic Association Studies Genetic Association Studies Genetic Predisposition to Disease Genetic Predisposition to Disease Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (28)

Cited by (6)

Source provenance

europepmc
last seen: 2026-10-11T09:27:45.537177+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:27:56.761287+00:00
License: CC0 · commercial use OK