Endosalpingiosis: More than just an incidental finding at the time of gynecologic surgery?

Esselen KM, Katharine M. Esselen, Kathryn L. Terry, Anicka Samuel, Samuel A, Elias KM, Kevin M. Elias, Michelle Davis, William R. Welch, Welch WR, Michael G Muto, Muto MG, Shu-Wing Ng, Shu‐Wing Ng, Ng SW, Berkowitz RS, Ross S. Berkowitz
Gynecologic Oncology · 2016 · vol. 142(2) , pp. 255–260 · doi:10.1016/j.ygyno.2016.05.036 · PMID:27261327 · W2410697981
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Endosalpingiosis was more frequently observed with concurrent endometriosis, uterine cancer, and ovarian cancers, particularly serous borderline, clear cell, and invasive mucinous subtypes.

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Abstract

OBJECTIVE: To describe the clinical characteristics of patients with endosalpingiosis (ES) and examine its association with endometriosis and gynecologic malignancies. METHODS: We queried the medical record for patients who underwent gynecologic surgery (Gynecologic Surgery Cohort (GSC), n=58,161) from 1998 to 2013 at a single institution for the presence of "endosalpingiosis" (ES). Demographic and clinical characteristics were collected for patients with pathologically confirmed ES (n=838). Within GSC, we compared the frequency of endometriosis and gynecologic malignancies with and without ES. We estimated the expected distribution of ovarian cancer subtypes using cases from the New England Case Control Study (NECC). We used chi-square tests to test for significant differences in frequency distributions and unconditional logistic regression to calculate multivariate odds ratios for the association between ES and ovarian cancer subtypes. RESULTS: We observed concurrent endometriosis (p<0.0001), uterine cancer (p<0.0001), and ovarian cancer (p<0.0001) more frequently in women with ES. Women from the GSC with ES and ovarian cancer were more likely to have serous borderline (OR=10.2, 95% CI=5.1-20.7), clear cell (OR=3.0, 95% CI=1.1-8.0), and invasive mucinous tumors (OR=5.0, 95% CI=1.5-16.6) as compared to ovarian cancer cases from the NECC without ES, after accounting for age, race, menopausal status, parity, tubal ligation, and endometriosis. CONCLUSION: Women with ES are more likely to also be diagnosed with endometriosis, uterine, and ovarian cancers. Further study is needed to understand these associations so we may appropriately counsel patients with ES diagnosed at time of gynecologic surgery.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Fallopian Tube Diseases Gynecologic Surgical Procedures Ovarian Neoplasms Uterine Neoplasms Adolescent Adolescent Adult Adult Aged Aged Aged, 80 and over Aged, 80 and over Endometriosis Endometriosis Fallopian Tube Diseases Fallopian Tube Diseases Female Female Gynecologic Surgical Procedures

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