Overexpression of microRNA‐542‐3p attenuates the differentiating capacity of endometriotic stromal cells

Shamima Sultana, Takeshi Kajihara, Yumi Mizuno, Tomomi Sato, Tatsuo Oguro, Machiko Kimura, Masumi Akita, Osamu Ishihara
Reproductive medicine and biology · 2017 · vol. 16(2) , pp. 170–178 · doi:10.1002/rmb2.12028 · PMID:29259466 · PMC5661816 · W2600703623
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This study found that overexpressing microRNA-542-3p in human ectopic endometrial stromal cells impairs their differentiating capacity and increases their migration and invasion potential.

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Abstract

Abstract Aim Endometriosis is defined as the presence of endometrial glandular and stromal cells outside of the uterine cavity. A previous study reported that micro RNA (miR)‐542‐3p plays a critical role in eutopic endometrial decidualization. This study aims to clarify the potential role of miR‐542‐3p and the target gene, IGFBP ‐1 (insulin‐like growth factor‐binding protein 1), in the impairment of the decidualizing capacity of human ectopic endometrial stromal cells ( HE c ESC s). Methods In vitro analysis of primary undifferentiated and decidualizing human eutopic endometrial stromal cells ( HE u ESC s) and HE c ESC s was conducted. The primary HE u ESC s or HE c ESC s were expanded in culture and decidualized with 8‐bromo‐cyclic adenosine monophosphate (8‐bromo‐ cAMP ) and medroxyprogesterone acetate ( MPA ). Results The morphological and biological differentiating capacities of the HE c ESC s were markedly impaired. In contrast to the HE u ESC s, the HE c ESC s that were treated with the decidual stimulus retained the mesenchymal phenotype and capacity for migration. The down‐regulation of miR‐542‐3p in the HE c ESC s treatment with 8‐bromo‐ cAMP and MPA was much weaker than that of the HE u ESC s. High expression of miR‐542‐3p led to a significant decrease in the expression of IGFBP 1 in the HE c ESC s. Conclusion Impairment of the differentiating capacity by the overexpression of miR‐542‐3p could influence the capacity for migration and invasion of endometriotic cells in an ectopic environment.

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endometriosis

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