Histologic features associated with hormonal responsiveness of ectopic endometrium

D A Metzger, Déborah Metzger, Metzger DA, Szpak CA, C A Szpak, Cheryl A. Szpak, Haney AF, A F Haney
Fertility and sterility · 1993 · vol. 42(3) , pp. 324 · doi:10.1016/0020-7292(93)90245-r · PMID:8419228 · W2404217025
Observational OA: closed CC0 ⤵ 21 in-corpus citations
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This study correlated histologic features of ectopic endometrium with hormonal responsiveness, finding more stroma in synchronous implants and increased fibrosis/surface epithelium associated with impaired response.

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Abstract

OBJECTIVE: To correlate histologic parameters of endometriosis with hormonal responsiveness. DESIGN: Seven hundred sixty-eight unselected endometriotic implants and the corresponding intrauterine endometrium from 196 patients were classified by standard endometrial dating criteria. In addition, other histologic characteristics of endometriotic implants such as the amount of stroma, amount of fibrosis, the presence of surface epithelium, presence of focal hemorrhage, and gland characteristics were also noted. SETTING: Academic tertiary referral center. MAIN OUTCOME MEASURES: Comparison of histologic dating between endometriotic implants and the corresponding endometrium as a function of histologic parameters. RESULTS: Implants that were synchronous with the corresponding eutopic endometrium had more stroma than those that were out of phase. The amount of fibrosis was inversely related to hormonal responsiveness. The presence of surface epithelium in implants was also associated with an impaired response (28.0% versus 48.0% in phase). Endometriomas were found to be in phase with the corresponding endometrium less often than other types of implants (21.7% versus 43.3%). Although endometriomas had similar amounts of stroma when compared with other implants, they had significantly more fibrosis (850.2 microns versus 195.0 microns). CONCLUSIONS: These results suggest that the unpredictable response of endometriotic implants to cyclic endogenous hormones and hormonal therapy may be related to the architectural relationships between the cellular elements found in normal endometrium.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Hormones Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Female Female Fibrosis Fibrosis Hormones Hormones Humans Humans Infertility, Female Infertility, Female

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

Cited by (21)

Source provenance

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License: CC0 · commercial use OK