Danazol in autoimmune haemolytic anaemia

Jean‐Michel Pignon, J M Pignon, Emmanuelle Poirson, E Poirson, H Rochant
British journal of haematology · 1993 · vol. 83(2) , pp. 343–345 · doi:10.1111/j.1365-2141.1993.tb08293.x · PMID:8457484 · W2131010849
Other OA: closed CC0 ⤵ 7 in-corpus citations
View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-13 ⓘ

Danazol combined with prednisone in adult warm antibody autoimmune hemolytic anemia patients resulted in long-lasting responses in 80% of newly diagnosed and 60% of refractory/relapsed cases with minimal side effects.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Ten adult patients with warm antibody haemolytic anaemia at initial presentation and seven other patients with either refractory AIHA (two patients) or who relapsed after an initial response to prednisone (five patients) were treated with both Danazol and prednisone. 80% of the first group, but also 60% of the second group displayed long-lasting responses (mean follow up 21 months). Minimal side-effects occurred. Finally, addition of Danazol at presentation in warm AIHA may decrease the duration of prednisone therapy and markedly reduce the necessity of second-line splenectomy which is usually required in many patients.

My notes (saved in your browser only)

MeSH descriptors

Anemia, Hemolytic, Autoimmune Danazol Adolescent Adult Aged Aged, 80 and over Anemia, Hemolytic, Autoimmune Danazol Drug Therapy, Combination Female Humans Male Middle Aged Prednisone Prednisone Retrospective Studies

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (10)

Cited by (5)

Source provenance

openalex
last seen: 2026-05-11T05:49:40.447239+00:00
pubmed
last seen: 2026-10-08T21:59:37.277143+00:00
License: CC0 · commercial use OK