Endometriosis-associated infertility and the efficacy of dienogest

Mekan R. Orazov, V.E. Radzinsky, Evgeny D. Dolgov
In: Russian Journal of Human Reproduction · 2025 · vol. 31(5) , pp. 58 · doi:10.17116/repro20253105158 · W4416087020
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review explores the pathogenetic mechanisms of implantation failure in endometriosis-associated infertility and discusses treatment options including dienogest.

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The paper studies infertility associated with endometriosis and evaluates the efficacy of dienogest in that context, using a narrative review/overview structure rather than original experimental data. It synthesizes existing information on how endometriosis contributes to subfertility and how dienogest has been assessed in relation to reproductive outcomes, including evidence drawn from prior research. A stated limitation is that the provided text does not present new trial results or a defined study protocol with quantitative outcomes, indicating reliance on referenced literature and potential variability across included studies. This paper is centrally about endometriosis — endometriosis-associated infertility and the efficacy of dienogest.

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Abstract

Endometriosis remains one of the key challenges in reproductive medicine in the 21st century. One in ten women of reproductive age has this condition, the main clinical manifestations of which are chronic pelvic pain and infertility. It should be noted that implantation failures are common in patients with endometriosis-associated infertility undergoing assisted reproductive technology (ART). This article examines the main pathogenetic mechanisms of implantation failure in endometriosis-associated infertility and treatment options.
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Сайт издательства «Медиа Сфера» содержит материалы, предназначенные исключительно для работников здравоохранения. Закрывая это сообщение, Вы подтверждаете, что являетесь дипломированным медицинским работником или студентом медицинского образовательного учреждения. Результаты поиска: 0 Бесплодие, ассоциированное с эндометриозом, и эффективность диеногеста Журнал: Проблемы репродукции. 2025;31(5): 58‑63 Прочитано: 929 раз Как цитировать: Литература / References: - International Working Group of AAGL, ESGE, ESHRE and WES; Tomassetti C, Johnson NP, Petrozza J, Abrao MS, Einarsson JI, Horne AW, Lee TTM, Missmer S, Vermeulen N, Zondervan KT, Grimbizis G, De Wilde RL. An international terminology for endometriosis, 2021. Human Reproduction Open. 2021;(4):hoab029. https://doi.org/10.1093/hropen/hoab029 - Allaire C, Bedaiwy MA, Yong PJ. Diagnosis and management of endometriosis. 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Reproductive Biology and Endocrinology. 2018;16(1):121. https://doi.org/10.1186/s12958-018-0414-2 - Prapas Y, Goudakou M, Matalliotakis I, Kalogeraki A, Matalliotaki Ch, Panagiotidis Y, Ravanos K, Prapas N. History of Endometriosis may Adversely Affect the Outcome in Menopausal Recipients of Sibling Oocytes. Reproductive BioMedicine Online. 2012; 25(5):543-548. https://doi.org/10.1016/j.rbmo.2012.07.020 - Hjordt Hansen MV, Dalsgaard T, Hartwell D, Skovlund ChW, Lidegaard O. Reproductive prognosis in endometriosis. A national cohort study. Acta Obstetricia et Gynecologica Scandinavica. 2014;93(5): 483-489. https://doi.org/10.1111/aogs.12373 - Ebrahimpoor M, Dehghani Firouzabadi R, Javaheri A, Shamsi F, Dashti S. The Impact of Endometriosis on Reproductive Outcomes in ART Cycles. Advanced Biomedical Research. 2024;13(1):89. https://doi.org/10.4103/abr.abr_436_23 - Gruber TM, Mechsner S. Pathogenesis of endometriosis: the origin of pain and subfertility. 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Accessed September 23, 2025. https://www.eshre.eu/Guidelines-and-Legal/Guidelines/Endometriosis-guideline - Tarlatzis BC, Kolibianakis EM. GnRH agonists vs antagonists. Best Practice and Research Clinical Obstetrics and Gynaecology. 2007; 21(1):57-65. https://doi.org/10.1016/j.bpobgyn.2006.08.002 - Kim HJ, Kim SH, Oh YS, Lee SR, Chae HD. Dienogest May Reduce Estradiol-and Inflammatory Cytokine-Induced Cell Viability and Proliferation and Inhibit the Pathogenesis of Endometriosis: A Cell Culture-and Mouse Model-Based Study. Biomedicines. 2022; 10(11):2992. https://doi.org/10.3390/biomedicines10112992 - Zhong C, Gao L, Shu L, Hou Zh, Cai L, Huang J, Liu J, Mao Y. Analysis of IVF/ICSI outcomes in endometriosis patients with recurrent implantation failure: Influence on cumulative live birth rate. Frontiers in Endocrinology. 2021;12:640288. https://doi.org/10.3389/fendo.2021.640288 - Atwa KA, Ibrahim ZM, El Bassuony EM, Taha OT, Ibrahim SAH, Ibrahim MF. Ovarian reserve after Dienogest therapy versus laparoscopic cystectomy for unilateral endometriomas: A randomized clinical trial. Journal of Endometriosis and Pelvic Pain Disorders. 2024;16(2):22840265241230717. https://doi.org/10.1177/22840265241230717 - Shao W, Li Y, Wang Y. Impact of dienogest pretreatment on IVF-ET outcomes in patients with endometriosis: a systematic review and meta-analysis. Journal of Ovarian Research. 2023;16(1):166. https://doi.org/10.1186/s13048-023-01245-8 - Barra F, Lagana AS, Scala C, Garzon S, Ghezzi F, Ferrero S. Pretreatment with dienogest in women with endometriosis undergoing IVF after a previous failed cycle. Reproductive Biomedicine Online. 2020;41(5):859-868. https://doi.org/10.1016/j.rbmo.2020.07.022 Подтверждение e-mail На [email protected] отправлено письмо со ссылкой для подтверждения e-mail. Перейдите по ссылке из письма, чтобы завершить регистрацию на сайте. Подтверждение e-mail Мы используем файлы cооkies для улучшения работы сайта. 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Condition tags

endometriosischronic_pelvic_paininfertility

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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