Global, regional, and national burden of endometriosis among women of reproductive age, 1990–2021: Insights from the global burden of disease study 2021

Jun Zhang, Mengduan Pang, Ling Li, Chuanjia Guo
PloS one · 2025 · vol. 20(11) , pp. e0337074 · doi:10.1371/journal.pone.0337074 · PMID:41296705 · PMC12654899 · W4416707584
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This study analyzed global endometriosis burden in reproductive-aged women from 1990-2021, finding fluctuating disease burden influenced by population size and socioeconomic development.

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Abstract

BACKGROUND: Endometriosis is a common gynecological disorder among women of reproductive age worldwide. This study aims to examine global patterns of endometriosis disease burden among reproductive-aged women and to evaluate its correlation with socioeconomic development indices. METHODS: This study conducted a comprehensive analysis of endometriosis disease burden using epidemiological parameters from the Global Burden of Disease (GBD) 2021 database, including incidence rates, prevalence rates, Disability-Adjusted Life Years (DALYs), and corresponding age-standardized rates. Through stratified analyses at global, regional, and national levels, we systematically evaluated the disease burden patterns among reproductive-aged women and performed correlation analysis with socioeconomic development indices. RESULTS: We found that the highest incidence of endometriosis among women of reproductive age globally occurs in the 20-24 age group, with an incidence rate of 399.49 per 100,000 in 1990 and 304.31 per 100,000 in 2021. The results show that the global disease burden of endometriosis is mainly influenced by population size, followed by epidemiological changes. Compared to countries with a medium Social Development Index (SDI), the disease burden of endometriosis in low and high SDI regions fluctuated significantly from 1990 to 2021. In most countries with SDI values between 0.2 and 0.6, the burden of endometriosis showed a gradual decline. CONCLUSION: Endometriosis remains a significant public health issue for women of reproductive age globally. Although the global disease burden of endometriosis among women of reproductive age showed a slight decline from 1990 to 2021, the disease burden continues to fluctuate in certain regions and countries. In light of the differences in the disease burden of endometriosis across regions and countries, regionalized disease management strategies are expected to be developed in the future.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Global Burden of Disease Global Burden of Disease Global Burden of Disease Global Burden of Disease Global Burden of Disease Global Burden of Disease Global Burden of Disease

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (47)

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