Determination of cytokines for assessment of inflammatory status at genital endometriosis

Leila Appazova, Lyudmila Akhmaltdinova, Yasminur Turdybekova, Irina L. Kopobayeva, Zhanna Amirbekova
In: Bangladesh Journal of Medical Science · 2024 · vol. 23(1) , pp. 121–129 · doi:10.3329/bjms.v23i1.70697 · W4390486777
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This study found significantly higher serum levels of IL-6, IL-8, and TNF-α in women with genital endometriosis and established their diagnostic significance for predicting the condition.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-09 · read from full text ⓘ

This study investigated serum cytokine profiles in 28 women with genital endometriosis versus 20 healthy non-pregnant controls, measuring IL-6, IL-8, IL-18, TNF-α, and MIF using multiplex immunofluorescence with XMap technology. IL-6, IL-8, and TNF-α levels were significantly higher in endometriosis (IL-6 p=0.037; IL-8 p<0.001; TNF-α p<0.001), while IL-18 and MIF showed no significant differences (p=0.630 and p=0.421). The authors reported diagnostic sensitivity/specificity values for predicting genital endometriosis of 75.0%/60.0% for IL-6, 100.0%/90.0% for IL-8, and 92.9%/85.0% for TNF-α, with the major limitation being the small sample size (48 total participants). This paper is centrally about endometriosis — it profiles serum cytokines to assess inflammatory status in genital endometriosis and evaluates diagnostic performance of specific cytokines.

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Abstract

Objective: The Aim of the research was to study the profile of serum cytokines in patients with genital endometriosis, as well as to evaluate the sensitivity and specificity of any single cytokine or combination of cytokines in predicting the inflammatory status in endometriosis. Material and methods: The study included 48 patients. They were divided into two groups: I group (experimental) – 28 women with genital endometriosis, II group (control) - 20 healthy non-pregnant women. For the determination of serum biomarkers (IL-6, IL-8, IL-18, TNF-α, MIF) the multiplex immunofluorescence method with XMap technology was used. Results: There were no statistical differences in IL-18 and MIF levels between the studied groups (p = 0.630 and p = 0.421). However, serum levels of IL-6, IL-8, TNF-α were significantly different (respectively, p = 0.037, p < 0.001, p < 0.001). In women with endometriosis the levels of IL-8 and TNF-α were increased 5 times, and level of IL-6 was increased 3 times. The diagnostic significance of IL-6, IL-8 and TNF-α levels for predicting genital endometriosis was 75.0% and 60.0%; 100.0% and 90.0%; 92.9% and 85.0%, respectively. Conclusions: The levels of IL-6, IL-8, and TNF-α were significantly higher in patients with genital endometriosis. The diagnostic significance of IL-6, IL-8 and TNF-α levels for predicting genital endometriosis was also established with the determination of the sensitivity and specificity of the model. Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 121-129
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Objective

The Aim of the research was to study the profile of serum cytokines in patients with genital endometriosis, as well as to evaluate the sensitivity and specificity of any single cytokine or combination of cytokines in predicting the inflammatory status in endometriosis.

Material and methods

The study included 48 patients. They were divided into two groups: I group (experimental) – 28 women with genital endometriosis, II group (control) - 20 healthy non-pregnant women. For the determination of serum biomarkers (IL-6, IL-8, IL-18, TNF-α, MIF) the multiplex immunofluorescence method with XMap technology was used.

Results

There were no statistical differences in IL-18 and MIF levels between the studied groups (p = 0.630 and p = 0.421). However, serum levels of IL-6, IL-8, TNF-α were significantly different (respectively, p = 0.037, p < 0.001, p < 0.001). In women with endometriosis the levels of IL-8 and TNF-α were increased 5 times, and level of IL-6 was increased 3 times. The diagnostic significance of IL-6, IL-8 and TNF-α levels for predicting genital endometriosis was 75.0% and 60.0%; 100.0% and 90.0%; 92.9% and 85.0%, respectively.

Conclusions

The levels of IL-6, IL-8, and TNF-α were significantly higher in patients with genital endometriosis. The diagnostic significance of IL-6, IL-8 and TNF-α levels for predicting genital endometriosis was also established with the determination of the sensitivity and specificity of the model. Bangladesh Journal of Medical Science Vol. 23 No. 01 January’24 Page : 121-129 Downloads 376 467 Downloads Published How to Cite Issue Section License Copyright (c) 2024 Leila Appazova, Lyudmila Akhmaltdinova, Yasminur Turdybekova, Irina Kopobayeva, Zhanna Amirbekova This work is licensed under a Creative Commons Attribution 4.0 International License. Authors who publish in the Bangladesh Journal of Medical Science agree to the following terms that: - Authors retain copyright and grant Bangladesh Journal of Medical Science the right of first publication of the work. Articles in Bangladesh Journal of Medical Science are licensed under a Creative Commons Attribution 4.0 International License CC BY-4.0.This license permits use, distribution and reproduction in any medium, provided the original work is properly cited.- Authors are able to enter into separate, additional contractual arrangements for the distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgement of its initial publication in this journal. - Authors are permitted to post their work online (e.g., in institutional repositories or on their website) as it can lead to productive exchanges, as well as greater citation of published work.

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endometriosis

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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