Complications of unopposed oestrogen following radical surgery for endometriosis

M Taylor, P. Bowen-Simpkins M . Taylor, Taylor M, P Bowen-Simpkins, Bowen-Simpkins P, Barrington J, J Barrington
Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology · 1999 · vol. 19(6) , pp. 647–648 · doi:10.1080/01443619963950 · PMID:15512424 · W2132192874
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⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-28 ⓘ

This paper reports on four patients who experienced endometriosis recurrence and one who developed cancer after receiving unopposed estrogen therapy post-surgery, suggesting combined estrogen/progestogen or tibolone therapy.

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Abstract

Four cases are presented here of patients who had total abdominal hysterectomy and bilateral salpingooophorectomy for severe endometriosis. All were eventually placed on unopposed oestrogen replacement therapy, two immediately and the other two after a few months. All subsequently developed recurrence of their endometriosis whilst on oestrogen therapy, one developing an endometroid carcinoma. All required surgery and three were placed on continuous oestrogen/progestogen preparation or alternatively tibolone (which has oestrogenic, progestogenic and androgenic properties) postoperatively. No further recurrence of their disease occurred. The literature was reviewed regarding oestrogen therapy for women who have had bilateral oophorectomy. There were various suggestions as to management but no report on using continuous oestrogen/ progestogen or tibolone. We suggest this as a logical form of replacement therapy for patients who have bilateraloophorectomy for severe endometriosis, as unopposed oestrogen therapy can cause recurrence.

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Condition tags

endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (13)

Cited by (7)

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