Modulating interaction of glutathione-S-transferase polymorphisms with smoking in endometriosis

Aban M, Meral Aban, Ertunc D, Devrim Ertunc, Devrim Ertunç, Tok EC, Ekrem C. Tok, Lülüfer Tamer, Tamer L, Lulufer Tamer, Arslan M, Murat Arslan, Saffet Dılek, Saffet Dilek, Dilek S
The Journal of reproductive medicine · 2007 · vol. 52(8) , pp. 715–21 · PMID:17879833 · W2415212335
Observational OA: closed CC0 ⤵ 16 in-corpus citations
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This study evaluated the interaction of glutathione-S-transferase polymorphisms and smoking in endometriosis, finding a joint effect where the GSTM1-null allele was more prevalent in smoking endometriosis patients.

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Abstract

OBJECTIVE: To evaluate the interaction of glutathione-S-transferase (GST) gene polymorphisms and smoking as a risk factor for endometriosis. STUDY DESIGN: The study group consisted of 150 women who were diagnosed by means of surgery and histopathology as having endometriosis. The control group consisted of 150 women who displayed no evidence of endometriosis during exploratory laparotomy or laparoscopy. We assessed the interaction of smoking and GSTM1 and GSTT1 polymorphisms in these patients. RESULTS: Logistic regression analyses showed that the GSTM1-null allele was associated with a significantly increased risk of endometriosis and smoking with a decreased risk of endometriosis separately. There was no association between endometriosis and the GSTT1-null allele. The interaction of smoking and GST polymorphisms showed a joint effect. We found that the GSTM1-null allele was more prevalent in active smoking endometriosis patients (63.4%) than in the controls (35.0%), and the difference was statistically significant. A similar tendency was also observed in the GSTT1 allele distribution. CONCLUSION: Genetic factors could modify the response to environmental pollutants in endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Glutathione S-Transferase pi Glutathione Transferase Polymorphism, Genetic Polymorphism, Genetic Smoking Adult Adult Case-Control Studies Case-Control Studies Endometriosis Endometriosis Endometriosis Female Female Genetic Markers Genetic Markers Genotype Genotype Glutathione S-Transferase pi

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

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