Effects of danazol on DNA synthesis in rat prostate

S. Sakamoto, Shinobu Sakamoto, T Mori, Takao Mori, K Sawaki, S Sassa, Shuji Sassa, Satoe Suzuki, S Suzuki, Y Sugiura, Yoshie Sugiura, H Kudo, Hideki Kudo, N Kasahara, Noriyuki Kasahara, H. Nagasawa, Hiroshi Nagasawa
The Prostate · 1993 · vol. 22(2) , pp. 119–124 · doi:10.1002/pros.2990220204 · PMID:8456051 · W2139061553
Lab / animal OA: closed CC0 ⤵ 1 in-corpus citation
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Danazol was found to reduce DNA synthesis enzyme activities and bromodeoxyuridine-immunoreactive cells in rat prostate, alongside decreased luteinizing hormone, testosterone, and organ weight.

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Abstract

Effects of danazol, an isoxazol derivative of the synthetic steroid 17 alpha-ethinyltestosterone, on activities of thymidylate synthetase and thymidine kinase, which are the DNA-synthesizing enzymes included in de novo and salvage pathways of pyrimidine metabolism, respectively, were investigated in rat prostate. Danazol markedly reduced plasma levels of luteinizing hormone and testosterone, and organ weight, both enzyme activities and bromodeoxyuridine-immunoreactive cells which were regarded as the S-phase cells in prostate. These results indicate that danazol shows a property as a potent antigonadotropin.

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MeSH descriptors

Danazol DNA Prostate Thymidine Kinase Thymidylate Synthase Animals Bromodeoxyuridine Danazol DNA Follicle Stimulating Hormone Follicle Stimulating Hormone Immunohistochemistry Luteinizing Hormone Luteinizing Hormone Male Organ Size Organ Size Prostate Prostate Prostate

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