Individual patient data meta-analysis of randomized evidence to assess the effectiveness of laparoscopic uterosacral nerve ablation in chronic pelvic pain

Jane Daniels, J P Daniels, L Middleton, Lee Middleton, T Xiong, Tengbin Xiong, Rita Champaneria, R Champaneria, N P Johnson, Neil Johnson, E M Lichten, Chris Sutton, C Sutton, P Vercellini, Paolo Vercellini, R Gray, Richard Gray, Robert K. Hills, R K Hills, Kevin Jones, K D Jones, Giorgio Aimi, G Aimi, K S Khan, Khalid S. Khan, as the International LUNA IPD Meta-analysis Collaborative Group, International LUNA IPD Meta-analysis Collaborative Group
Human Reproduction Update · 2010 · vol. 16(6) , pp. 568–576 · doi:10.1093/humupd/dmq031 · PMID:20634210 · W2142434343
Systematic review / meta-analysis OA: bronze CC0 ⤵ 18 in-corpus citations
📄 Open PDF View on OpenAlex View on PubMed View at publisher
⚙ AI-generated summary by gemini-2.5-flash-lite, 2026-06-07 ⓘ

An individual patient data meta-analysis of five randomized trials found no significant difference in worst pain over 12 months between laparoscopic uterosacral nerve ablation and no intervention for chronic pelvic pain.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

BACKGROUND: There have been conflicting results in randomized trials of the effects of laparoscopic uterosacral nerve ablation (LUNA) in chronic pelvic pain. Our objective was to perform a meta-analysis using individual patient data (IPD) to provide the most comprehensive and reliable assessment of the effectiveness of LUNA. METHODS: Electronic searches were conducted in the Medline, Embase, PsycInfo and Cochrane Library databases from database inception to August 2009. The reference lists of known relevant papers were searched for any further articles. Randomized trials comparing LUNA with no additional intervention were selected and authors contacted for IPD. Raw data were available from 862 women randomized into five trials. Pain scores were calibrated to a 10-point scale and were analysed using a multilevel model allowing for repeated measures. RESULTS: There was no significant difference between LUNA and No LUNA for the worst pain recorded over a 12 month time period (mean difference 0.25 points in favour of No LUNA on a 0-10 point scale, 95% confidence interval: -0.08 to 0.58; P = 0.1). CONCLUSIONS: LUNA does not result in improved chronic pelvic pain.

My notes (saved in your browser only)

Condition tags

chronic_pelvic_pain

MeSH descriptors

Ablation Techniques Laparoscopy Pelvic Pain Adolescent Adult Female Humans Pelvic Pain Randomized Controlled Trials as Topic Sacrococcygeal Region Sacrococcygeal Region Sacrococcygeal Region Treatment Outcome Uterus Uterus Uterus

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (43)

Cited by (17)

Source provenance

openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-10-08T21:07:47.794683+00:00
License: CC0 · commercial use OK