Bioinformatics-driven identification and validation of hub genes regulating endometriosis-related infertility within human granulosa cells

Jiahuan Luo; Huawei Wang; Ling Zhou; Jinyuan Wang; Mengjie Song; Yulin Cheng; Meng Rao; Shuhua Zhao; Li Tang; Tang Li

doi:10.1016/j.rbmo.2025.104826

Bioinformatics-driven identification and validation of hub genes regulating endometriosis-related infertility within human granulosa cells

Jiahuan Luo, Huawei Wang, Ling Zhou, Jinyuan Wang, Mengjie Song, Yulin Cheng, Meng Rao, Shuhua Zhao, Li Tang, Tang Li

Reproductive biomedicine online · 2025 · vol. 51(2) , pp. 104826 · doi:10.1016/j.rbmo.2025.104826 · PMID:40580573 · W4406377989

article OA: closed CC0

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This study used bioinformatics to identify and validate key genes in human granulosa cells that are associated with infertility caused by endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (63)

1H NMR- based metabolomics approaches as non- invasive tools for diagnosis of endometriosis via openalex
Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy via openalex
Altered transcriptome in cumulus cells of infertile women with advanced endometriosis with and without endometrioma via openalex
Analysis of differences in the transcriptomic profiles of eutopic and ectopic endometriums in women with ovarian endometriosis via openalex
Couples with mild male factor infertility and at least 3 failed previous IVF attempts may benefit from laparoscopic investigation regarding assisted reproduction outcome via openalex
Does Endometriosis Influence the Embryo Quality and/or Development? Insights from a Large Retrospective Matched Cohort Study via openalex
Endometrioma, the follicular fluid inflammatory network and its association with oocyte and embryo characteristics via openalex
Endometriosis and infertility: a committee opinion via openalex
Evidence based management of patients with endometriosis undergoing assisted conception: British fertility society policy and practice recommendations via openalex
High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners via openalex
Identification of key modules and candidate genes associated with endometriosis based on transcriptome data via bioinformatics analysis via openalex
Impact of endometriosis and its staging on assisted reproduction outcome: systematic review and meta-analysis via openalex
Impact of moderate-to-severe endometriosis on IVF cumulative live birth rate: a retrospective matched cohort study via openalex
Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients via openalex
Is Endometriosis More Common and More Severe Than It Was 30 Years Ago? via openalex
Is the profile of transcripts altered in the eutopic endometrium of infertile women with endometriosis during the implantation window? via openalex
Management of endometriosis-related infertility: Considerations and treatment options via openalex
Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects via openalex
Oocyte quality in women with infertility associated endometriosis via openalex
Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation via openalex
Overexpression of miR-200b-3p in Menstrual Blood-Derived Mesenchymal Stem Cells from Endometriosis Women via openalex
Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis via openalex
Prevalence and genesis of endometriosis via openalex
Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis via openalex
Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality via openalex
The effect of endometriosis on live birth rate and other reproductive outcomes in ART cycles: a cohort study via openalex
The Impact of Endometriosis on Embryo Quality in in-vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis via openalex
Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu via openalex
Transcriptome Profiling of Eutopic and Ectopic Endometrial Stromal Cells in Women with Endometriosis Based on High-Throughput Sequencing via openalex
What Do the Transcriptome and Proteome of Menstrual Blood-Derived Mesenchymal Stem Cells Tell Us about Endometriosis? via openalex
W4389684551 via openalex
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W6773174225 via openalex
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W2029074866 via openalex
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SciLite annotations

organisms 1

human

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-04T00:00:01.174412+00:00
pubmed: last seen: 2026-06-02T00:31:24.865732+00:00
scilite: last seen: 2026-05-18T04:26:01.642840+00:00

License: CC0 · commercial use OK

[1] 1H NMR- based metabolomics approaches as non- invasive tools for diagnosis of endometriosis via openalex

[2] Aldosterone in Gynecology and Its Involvement on the Risk of Hypertension in Pregnancy via openalex

[3] Altered transcriptome in cumulus cells of infertile women with advanced endometriosis with and without endometrioma via openalex

[4] Analysis of differences in the transcriptomic profiles of eutopic and ectopic endometriums in women with ovarian endometriosis via openalex

[5] Couples with mild male factor infertility and at least 3 failed previous IVF attempts may benefit from laparoscopic investigation regarding assisted reproduction outcome via openalex

[6] Does Endometriosis Influence the Embryo Quality and/or Development? Insights from a Large Retrospective Matched Cohort Study via openalex

[7] Endometrioma, the follicular fluid inflammatory network and its association with oocyte and embryo characteristics via openalex

[8] Endometriosis and infertility: a committee opinion via openalex

[9] Evidence based management of patients with endometriosis undergoing assisted conception: British fertility society policy and practice recommendations via openalex

[10] High prevalence of endometriosis in infertile women with normal ovulation and normospermic partners via openalex

[11] Identification of key modules and candidate genes associated with endometriosis based on transcriptome data via bioinformatics analysis via openalex

[12] Impact of endometriosis and its staging on assisted reproduction outcome: systematic review and meta-analysis via openalex

[13] Impact of moderate-to-severe endometriosis on IVF cumulative live birth rate: a retrospective matched cohort study via openalex

[14] Increased expression of c-fos protein associated with increased matrix metalloproteinase-9 protein expression in the endometrium of endometriotic patients via openalex

[15] Is Endometriosis More Common and More Severe Than It Was 30 Years Ago? via openalex

[16] Is the profile of transcripts altered in the eutopic endometrium of infertile women with endometriosis during the implantation window? via openalex

[17] Management of endometriosis-related infertility: Considerations and treatment options via openalex

[18] Novel therapeutic targets to improve IVF outcomes in endometriosis patients: a review and future prospects via openalex

[19] Oocyte quality in women with infertility associated endometriosis via openalex

[20] Outcome of patients with endometriosis in assisted reproduction: results from in-vitro fertilization and oocyte donation via openalex

[21] Overexpression of miR-200b-3p in Menstrual Blood-Derived Mesenchymal Stem Cells from Endometriosis Women via openalex

[22] Prediction of pregnancy in infertile women based on the American Society for Reproductive Medicine's revised classification of endometriosis via openalex

[23] Prevalence and genesis of endometriosis via openalex

[24] Reproductive, obstetric, and perinatal outcomes of women with adenomyosis and endometriosis: a systematic review and meta-analysis via openalex

[25] Single-cell RNA sequencing of oocytes from ovarian endometriosis patients reveals a differential transcriptomic profile associated with lower quality via openalex

[26] The effect of endometriosis on live birth rate and other reproductive outcomes in ART cycles: a cohort study via openalex

[27] The Impact of Endometriosis on Embryo Quality in in-vitro Fertilization/Intracytoplasmic Sperm Injection: A Systematic Review and Meta-Analysis via openalex

[28] Transcriptome meta-analysis reveals differences of immune profile between eutopic endometrium from stage I-II and III-IV endometriosis independently of hormonal milieu via openalex

[29] Transcriptome Profiling of Eutopic and Ectopic Endometrial Stromal Cells in Women with Endometriosis Based on High-Throughput Sequencing via openalex

[30] What Do the Transcriptome and Proteome of Menstrual Blood-Derived Mesenchymal Stem Cells Tell Us about Endometriosis? via openalex

[31] W4389684551 via openalex

[32] W6699474341 via openalex

[33] W6773174225 via openalex

[34] W6796337283 via openalex

[35] W1993445275 via openalex

[36] W2029074866 via openalex

[37] W2035961703 via openalex

[38] W2048071779 via openalex

[39] W2061096783 via openalex

[40] W2067201490 via openalex

[41] W2097972396 via openalex

[42] W2147242642 via openalex

[43] W2153114583 via openalex

[44] W2158217645 via openalex

[45] W2159675211 via openalex

[46] W2790972191 via openalex

[47] W2810070345 via openalex

[48] W2890984240 via openalex

[49] W2940044844 via openalex

[50] W2967732553 via openalex

[51] W2981878147 via openalex

[52] W2996846877 via openalex

[53] W3038426473 via openalex

[54] W3134873486 via openalex

[55] W3158233488 via openalex

[56] W4220769835 via openalex

[57] W4220831425 via openalex

[58] W4288802449 via openalex

[59] W4308834893 via openalex

[60] W4312194622 via openalex

[61] W4313259819 via openalex

[62] W4321004325 via openalex

[63] W4385950430 via openalex