Mutation of galactose-1-phosphate uridyl transferase and its association with ovarian cancer and endometriosis

Morland SJ, S J Morland, Sarah J. Morland, X Jiang, Jiang X, Xiuxian Jiang, Hitchcock A, A Hitchcock, Andrew Hitchcock, Eric J. Thomas, E J Thomas, Thomas EJ, Ian Campbell, I G Campbell
International journal of cancer · 1998 · vol. 77(6) , pp. 825–827 · doi:10.1002/(sici)1097-0215(19980911)77:6<825::aid-ijc4>3.0.co;2-w · PMID:9714048 · W2086797611
article OA: closed CC0 ⤵ 26 in-corpus citations
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This study found the N314D mutation in galactose-1-phosphate uridyl transferase was more frequent in serous and undifferentiated ovarian cancers, but not in endometriosis or other ovarian cancer subtypes.

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Abstract

Impaired galactose metabolism has been proposed as a risk factor for ovarian cancer and endometriosis, which is a putative precursor of endometrioid and clear cell histological sub-types of ovarian cancer. The prevalence of the most common galactose-I-phosphate uridyl transferase gene mutations, Q188R and N314D, was assessed in 206 women with ovarian cancer, 78 women with endometriosis and 248 controls. No Q188R mutations were found in any of the groups. A statistically significant increase in the frequency of N314D mutations was observed in women with serous and undifferentiated histological sub-types of ovarian cancer, but not mucinous, endometrioid or clear cell sub-types. There were no significant differences observed in the N314D mutation frequency between women with endometriosis (18%) and controls (17%). Our results support previous reports of an association of impaired galactose metabolism with serous and undifferentiated ovarian cancers but contradict previous findings of increased N314D mutation frequencies among women with endometriosis and endometrioid and clear cell sub-types ovarian cancer.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Mutation Ovarian Diseases Ovarian Diseases Ovarian Neoplasms Ovarian Neoplasms UTP-Hexose-1-Phosphate Uridylyltransferase Adult DNA Primers Endometriosis Female Humans Ovarian Diseases Ovarian Neoplasms Polymerase Chain Reaction UTP-Hexose-1-Phosphate Uridylyltransferase

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