Distribution of malignant neoplasms among patients with endometriosis: an epidemiological study

Н Н Байрамова, А. Э. Протасова, Г. А. Раскин, Maria I. Yarmolinskaya, Anna A. Tsypurdeyeva, Maria D. Gavrilova
In: Journal of obstetrics and women's diseases · 2018 · vol. 67(6) , pp. 5–12 · doi:10.17816/jowd6765-12 · W2914890106
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This epidemiological study of 1551 endometriosis patients found a low overall cancer incidence, but an increased risk for certain malignancies, notably ovarian cancer.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This epidemiological cohort study assessed the incidence and distribution of malignant neoplasms in 1,551 women with surgically verified endometriosis from the Saint Petersburg 122 Clinical Hospital discharge register (1996–2006), linking records to the Saint Petersburg Cancer Agency through 2016. Malignancies were identified in 6.3% of patients (98 cases) over a median follow-up of 12.2 years, with the most prevalent cancers being breast (29), ovarian (7), endometrial (7), thyroid (7), colorectal (6), melanoma (6), non-Hodgkin’s lymphoma (4), and glioblastoma (3). The paper notes limitations related to its design, including that risk analyses excluded women after specific surgeries (e.g., oophorectomy for ovarian cancer risk; hysterectomy/pan-hysterectomy for endometrial and cervical cancer risk), which can affect comparability across cancer sites. This paper is centrally about endometriosis — it quantifies the incidence and site distribution of malignancies among women with morphologically confirmed endometriosis, highlighting an increased risk pattern particularly for ovarian cancer.

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Abstract

Hypothesis/aims of study. The current analysis was undertaken to assess the incidence of malignant diseases in patients with endometriosis. Study design, materials and methods. This is a cohort study of women with surgically verified endometriosis retrieved from the Saint Petersburg 122 Clinical Hospital Discharge Register 1996–2006 (n = 1551). Data were linked to the Saint Petersburg Cancer Agency to identify cases of malignancy. Results. Malignant diseases were identified in 6.3% (n = 98) of cases. The median follow-up was 12.2 (7.5) years. Breast cancer (n = 29), ovarian cancer (n = 7), endometrial cancer (n = 7), thyroid cancer (n = 7), colorectal cancer (n = 6), melanoma (n = 6), non-Hodgkin’s lymphoma (n = 4), and glioblastoma (n = 3) were prevalent. Conclusion. The incidence of cancer in patients with endometriosis is low. Women with endometriosis have an increased risk of some malignancies, particularly ovarian cancer.

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endometriosis

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