Evaluation of the effect of indomethacin and piroxicam administration before embryo transfer on pregnancy rate

Kumbasar S, Serkan Kumbasar, Gül Ö, Özer Gül, Aytek Şık, Şık A
Journal of Obstetrics and Gynaecology Research · 2017 · vol. 43(3) , pp. 536–542 · doi:10.1111/jog.13244 · PMID:28160506 · W2584034870
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Administration of indomethacin or piroxicam before embryo transfer did not significantly impact clinical pregnancy, implantation, or miscarriage rates in women undergoing IVF.

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Abstract

AIM: The aim of this study was to evaluate the effect of non-steroidal anti-inflammatory drug (NSAID) administration before embryo transfer (ET) on pregnancy rates in women undergoing in vitro fertilization/intracytoplasmic sperm injection ET. METHODS: Our study included 255 patients diagnosed with primary or secondary infertility caused by a male or tubal-related factor, endometriosis or unexplained factors. The patients were divided randomly into three groups. Two groups were administered oral piroxicam (10 mg capsules) or 100 mg indomethacin (rectal suppository), respectively, 1-2 h before ET. As a control, the third group did not receive any form of treatment before ET. Basal levels of follicle-stimulating hormone, luteinizing hormone, and level 17β-estradiol on the day of human chorionic gonadotropin administration, the collected and transferred number of embryos, and the number of grade A embryos obtained were determined in all patients. RESULTS: The implantation, clinical pregnancy, and miscarriage rates of the groups were compared. The clinical pregnancy rate per ET and the implantation rate were 35.2% and 12.15% in the piroxicam group, 31.7% and 10.9% in the indomethacin group, and 32.9% and 12.5% in the control, respectively. The miscarriage rates of groups 1, 2 and 3 were 12%, 11.7% and 11.7%, respectively (P = 0.964). The differences in clinical pregnancy rates among the groups were not statistically significant (P = 0.887). There were also no significant differences in the implantation rates (P = 0.842). CONCLUSION: These results suggest that NSAID administration before ET has no additional effect on pregnancy outcome in patients undergoing in vitro fertilization.

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Condition tags

endometriosisinfertility

MeSH descriptors

Anti-Inflammatory Agents, Non-Steroidal Embryo Transfer Indomethacin Infertility, Female Piroxicam Pregnancy Rate Adult Anti-Inflammatory Agents, Non-Steroidal Embryo Implantation Embryo Implantation Embryo Transfer Female Fertilization in Vitro Humans Indomethacin Infertility, Female Piroxicam Pregnancy Pregnancy Outcome

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