Differential expression of Lumican, Mimecan, Annexin A5 and Serotransferrin in ectopic and matched eutopic endometrium in ovarian endometriosis: a case-control study

Tahreem Sahar, Aruna Nigam, Shadab Anjum, Farheen Waziri, Shivi Jain, S K Jain, Saima Wajid
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2020 · vol. 37(1) , pp. 56–60 · doi:10.1080/09513590.2020.1824218 · PMID:32964764 · W3089212598
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This proteomic study found that Mimecan and Lumican proteins were upregulated in ectopic endometrium compared to matched eutopic endometrium from women with ovarian endometriosis.

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Abstract

AIM: Endometriosis is a debilitating disease marked by recurrent gynecological proliferations. The present study aimed at performing differential proteomic analysis of matched eutopic and ectopic endometrium from women with ovarian endometriosis. MATERIALS AND METHODS: Proteomes were resolved using nano LC-MS and further identified and quantified using ProteinLynx Global SERVER (PLGS) software. Selected proteins were further chosen for validation by real time-polymerase chain reaction (RT-PCR). RESULTS: The protein profiles uncovered several differentially expressed proteins in the diseased sample (ectopic endometrium) as compared to the reference sample (eutopic endometrium). The study involved an advanced proteomic approach, nano LC-MS, and validates for the first time the upregulation of Mimecan and Lumican proteins in endometriosis. CONCLUSIONS: These proteins may hence prove as potentially useful tools in the search for diagnostic markers for early detection of the disease.

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Condition tags

endometriosis

MeSH descriptors

Annexin A5 Endometriosis Endometrium Intercellular Signaling Peptides and Proteins Lumican Ovarian Diseases Transferrin Annexin A5 Biomarkers Biomarkers Case-Control Studies Endometriosis Endometrium Female Humans Intercellular Signaling Peptides and Proteins Lumican Ovarian Diseases Proteome Transferrin

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