Influence of Hormonal Factors, Number of Sexual Partners, Surgical Intervention on Gastrointestinal and Urogenital Microbiota of Patients Endometriosis

Han Do, Do H, Hung Do, Paula Díaz‐Sylvester, Paula Diaz-Sylvester, Groesch K, Kathleen Groesch, Wilson T, Teresa Wilson, Kristen Delfino, Kristin Delfino, J. Ricardo Loret de Mola, de Mola JRL, Andrea Braundmeier-Fleming, Braundmeier-Fleming A, Andrea Braundmeier‐Fleming
Archives of medical research · 2024 · vol. 55(8) , pp. 103112 · doi:10.1016/j.arcmed.2024.103112 · PMID:39500248 · W4404034100
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Endometriosis patients exhibited distinct GI/UG microbial dysbiosis, which hormonal and surgical interventions partially restored, while increased sexual partner numbers exacerbated this dysbiosis.

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Abstract

PROBLEM: Endometriosis is associated with gastrointestinal (GI) and urogenital (UG) microbial dysbiosis in patients with endometriosis (P-EOSIS). Sexual partner exposure may contribute to microbial dysbiosis but has not been studied in P-EOSIS. We hypothesized that sexual partner number, hormonal and surgical therapy would affect GI/UG microbial dysbiosis in P-EOSIS. METHODS OF STUDY: Urine, fecal and vaginal swabs from control (n = 15) and P-EOSIS (n = 33) were collected on the day of surgery (DOS) and ∼1-3 weeks post-surgical intervention (PSI). Control and P-EOSIS were grouped based on hormonal therapy (HT) to determine the effect of HT on microbial profiles, Control (HT n = 8; no HT n = 7) and P-EOSIS (HT n = 18; no HT n = 15). Samples underwent DNA extraction and sequencing of the V4 region of 16S rRNA gene. Sequences were processed using QIIME2 and amplicon sequence variants (ASV) were analyzed for microbial differences. Pearson's and Spearman correlation analyses determined associations among microbial features and sexual partner exposure. RESULTS: P-EOSIS had microbial dysbiosis characterized by unique GI/UG bacteria and altered microbial richness and diversity. Hormonal and surgical intervention in P-EOSIS restored GI microbial diversity. Increased sexual partner exposure decreased GI/UG microbial diversity. P-EOSIS who had 10 or more sexual partners had greater microbial dysbiosis compared to 4-6 partners. Surgical intervention negatively correlated with sexual partner numbers and GI/UG microbial abundance. DISCUSSION: Increased sexual partner exposure may enhance microbial dysbiosis in P-EOSIS and diminish the effectiveness of HT and surgical interventions.

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Condition tags

endometriosis

MeSH descriptors

Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis Dysbiosis

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (30)

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